Publications by authors named "Inge Wolf"
Background: Physical activity surveillance systems are important for public health monitoring but rely mostly on self-report measurement of physical activity. Integration of device-based measurements in such systems can improve population estimates, however this is still relatively uncommon in existing surveillance systems. This systematic review aims to create an overview of the methodology used in existing device-based national PA surveillance systems.
View Article and Find Full Text PDFThe COVID-19-pandemic forced many countries to close schools abruptly in the spring of 2020. These school closures and the subsequent period of distance learning has led to concerns about increasing inequality in education, as children from lower-educated and poorer families have less access to (additional) resources at home. This study analyzes differences in declines in learning gains in primary education in the Netherlands for reading, spelling and math, using rich data on standardized test scores and register data on student and parental background for almost 300,000 unique students.
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- Deregulated expression of c-myc and bcl-xL leads to the transformation of B cells, allowing researchers to induce differentiation of mouse pre-B cells into different B-cell types in lab settings.
- Through controlled overexpression of these oncogenes and stimulation, various pre-B and immature B1 cells can be directed to mature into functional B1-cell lines and Ig-secreting cells.
- The study of these cultured B1-cell lines provides insights into autoimmune diseases and the development of B1-cell malignancies.
Article Synopsis
- c-myc alone doesn't fully transform B cells; it needs additional cooperating genes for complete transformation.
- Researchers created doxycycline-inducible cDNA libraries from pre-B cell mRNA and tested them in c-myc-overexpressing cells, finding limited success in identifying a cooperative gene for transformation.
- The identified gene, a shortened form of Exosc1, showed promise in vivo, allowing for the survival and differentiation of B cells, suggesting that the host environment significantly impacts B-cell transformation.
This paper estimates the effects of attending medical school on health outcomes by exploiting that admission to medical school in the Netherlands is determined by a lottery. Among the applicants for medical school, people who attended medical school have on average 1.5 more years of completed education than people who did not.
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