Publications by authors named "Inge Klupka-Saric"
Epilepsy is a common neurologic disease and presents a major public health problem. Patients with epilepsy have unexpected occurrence of seizures with many triggered by existing triggering factors such as alcohol, stress etc. Other potential triggers include certain weather or atmospheric parameters and local geomagnetic activity.
View Article and Find Full Text PDFTo present a 29-year-old immunocompetent patient with neurosyphilitic changes characterized by multiple acute ischemic brain strokes along with significant narrowing of several large intracranial arteries. Ceftriaxone treatment for 14 days followed by benzathine benzylpenicillin weekly for additional 3 weeks, showed improvement in meningovascular changes.
View Article and Find Full Text PDFAim To assess trends in thrombolysis rates and door-to-needle times in University Hospital Mostar. Methods Data from the University Hospital Mostar Registry were used. Information on the number of ischaemic stroke patients, intravenous thrombolysis rates and "door-to-needle times" (DNT) were collected between January 2013 and December 2021.
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- Previous studies indicate that impaired fibrinolysis is linked to multiple sclerosis (MS), highlighting the roles of tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) in the disease.
- The research analyzed the association between genetic polymorphisms (TPA Alu I/D and PAI-1 4G/5G) and MS across four ethnically similar populations, involving 885 MS patients and 656 healthy controls.
- Findings revealed that TPA DD homozygosity reduces MS risk, while PAI-1 5G5G increases it, suggesting that gene interactions are significant in determining susceptibility to this complex disease.
Introduction: Multiple sclerosis (MS) is the most common, chronic debilitating disease in young adults characterized by a wide variety of neurological symptoms and unpredictable increasing disability. Worldwide, MS affects about 2.5 million people, with a female-to-male ratio of approximately 2:1.
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- Increased activity of angiotensin-converting enzyme (ACE) has been suggested to play a role in multiple sclerosis (MS), prompting researchers to investigate the association between ACE gene polymorphism and MS.
- A study was conducted involving 170 MS patients and 170 healthy controls in Bosnia and Herzegovina, employing the polymerase chain reaction method for genotyping.
- Results indicated no significant differences in ACE I/D genotype distribution or allele frequencies between MS patients and healthy controls, concluding that ACE I/D polymorphism is not a risk factor for MS or its severity in this population.
The aim of this study was to investigate the selected indicators of multiple sclerosis (MS) in Herzegovina (Western Herzegovina Canton and Herzegovina-Neretva Canton). By using all available health and medical sources in the studied area and using McDonald's criteria, a total of 96 patients were identified in the period from 1996 to 2006. Results of the study show that the crude prevalence of MS was 30.
View Article and Find Full Text PDFObjectives: To determine epidemiological rates of multiple sclerosis (MS) in western Herzegovina.
Patients And Methods: We analysed data from 81 MS patients (49 females, 32 males) on the prevalence day, 31 December 2003. Patient information was obtained from a search of all available medical records from the period 1994-2003 in the investigated area.