Publications by authors named "Inge F Wijnbergen"
Article Synopsis
- Despite primary PCI treatment for STEMI, patients still face high risks of heart failure and late death due to microvascular dysfunction, measured by IMR.
- The study aims to determine if IMR is an independent predictor of cardiac death, identify the optimal cutoff value of IMR, and compare it to other cardiac parameters.
- Results from 1,265 patients show that a higher IMR (especially >40) is associated with increased cardiac mortality and hospitalization for heart failure, establishing an optimal cutoff value of 70 for predicting cardiac death.
Unlabelled: The optimal treatment strategy for coronary bifurcation lesions by percutaneous coronary intervention (PCI) is complex and remains a subject of debate. Current guidelines advise a stepwise provisional approach with optional two-stent strategy. However, a two-stent strategy, both upfront and stepwise provisional, is technically demanding.
View Article and Find Full Text PDFBackground: The differences in outcomes and process parameters for NSTEMI patients who are directly admitted to an intervention centre and patients who are first admitted to a general centre are largely unknown.
Hypothesis: There are differences in process indicators, but not for clinical outcomes, for NSTEMI who are directly admitted to an intervention centre and patients who are first admitted to a general centre.
Methods: We aim to compare process indicators, costs and clinical outcomes of non-ST-segment elevation myocardial infarction (NSTEMI) patients stratified by center of first presentation and revascularisation strategy.
Objectives: Spinal cord stimulation (SCS) is a treatment option for patients with refractory angina pectoris (RAP) which was first used in 1987 and led to a reduction in the number of angina pectoris episodes, less consumption of short-acting nitrates, and an improvement in the quality of life. The conventional mode of stimulation leads to paresthesia felt at the target area. In recent years novel modes of stimulation have been developed that are paresthesia free, such as "burst," "high-density (HD)," or "high-frequency/10 kHz" stimulation.
View Article and Find Full Text PDFArticle Synopsis
- This study explores treatment options for patients with significant issues in the left anterior descending coronary artery (LAD), where neither coronary artery bypass grafting (CABG) nor optimal medical therapy (OMT) has clear superiority due to uncertain long-term benefits.
- Conducting a retrospective analysis of 59 patients treated between 2015 and 2020, researchers measured outcomes across both CABG and OMT groups, focusing on mortality, heart attacks, revascularization, and angina severity over a two-year period.
- The findings show no significant differences in the primary and secondary health outcomes between the CABG and OMT groups after two years, suggesting that both treatment methods may be equally effective for
Objectives: The aim of this study was to determine the safety of selective intracoronary hypothermia during primary percutaneous coronary intervention (PPCI) in patients with anterior ST-segment elevation myocardial infarction (STEMI).
Background: Selective intracoronary hypothermia is a novel treatment designed to reduce myocardial reperfusion injury and is currently being investigated in the ongoing randomized controlled EURO-ICE (European Intracoronary Cooling Evaluation in Patients With ST-Elevation Myocardial Infarction) trial (NCT03447834). Data on the safety of such a procedure during PPCI are still limited.
Article Synopsis
- There has been a notable rise in research and knowledge about the coronary microcirculation over the last 20 years, despite these small vessels being invisible to the naked eye.
- Current measurement techniques for these vessels, like coronary flow reserve (CFR) and index of microvascular resistance (IMR), depend on the operator and require adenosine to enhance blood flow.
- A new thermodilution-based method using the Rayflow infusion catheter and Coroventis software has emerged, offering an accurate and operator-independent way to measure absolute coronary blood flow and resistance, validated against PET-CT and proven safe over the long term.
Article Synopsis
- A study investigated the safety and effectiveness of different drug-eluting stents (DES) in patients with ST-segment elevation myocardial infarction (STEMI) who underwent coronary interventions, finding no single DES superior to others.
- The analysis included data from 15 randomized controlled trials involving nearly 11,000 STEMI patients, focusing on outcomes like cardiac death, reinfarction, or revascularization over a median follow-up period of 3 years.
- Results showed that patients with first-generation DES experienced significantly lower risks of complications compared to those with bare-metal stents, but no notable difference was seen among various DES types themselves.
Aims: Echocardiography and tomographic imaging have documented dynamic changes in aortic stenosis (AS) geometry and severity during both the cardiac cycle and stress-induced increases in cardiac output. However, corresponding pressure gradient vs. flow relationships have not been described.
View Article and Find Full Text PDFAims: Hypothermia reduces reperfusion injury and infarct size in animal models of acute myocardial infarction if started before reperfusion. Human studies have not confirmed benefit, probably due to insufficient myocardial cooling and adverse systemic effects. This study sought to assess the safety and feasibility of a novel method for selective, sensor-monitored intracoronary hypothermia.
View Article and Find Full Text PDFA 72-year-old woman without cardiovascular history presented with acute substernal chest pain and dyspnoea. The electrocardiogram was normal, but the blood test analyses showed an elevated troponin T level. Emergency coronary angiography revealed normal epicardial coronary arteries, but the left ventriculogram demonstrated midventricular dilatation and akinesis with well-preserved contractility of the apex and base.
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