Publications by authors named "Ingaldi C"
Article Synopsis
- Long-term survivors of pancreatic cancer after surgery are rare, and a recent Italian survey aims to understand factors affecting their survival outcomes.
- The survey, endorsed by key oncological associations, gathered responses from surgeons to analyze demographics, clinical practices, and survival rates, revealing that long-term survival (LTS) is defined as being alive at 5 years post-surgery.
- Findings indicated improved survival rates for patients post-2013, especially in high-volume centers with multidisciplinary approaches, as well as those receiving neoadjuvant chemotherapy and having low-grade tumors.
Background: Long-term survivors (LTSs) after pancreatic resection of pancreatic ductal adenocarcinoma (PDAC) represent a particular subgroup of patients that remains poorly understood. The primary endpoint was to identify clinicopathological factors associated with LTSs after pancreatic resection for PDAC.
Methods: This was a retrospective study of patients who had undergone pancreatic resection for PDAC.
Background: The superiority of early drain removal (EDR) versus late (LDR) after pancreaticoduodenectomy (PD) has been demonstrated only in RCTs.
Methods: A meta-analysis was conducted using a random-effects model and trial sequential analysis. The critical endpoints were morbidity, redrainage, relaparotomy, and postoperative pancreatic fistula (CR-POPF).
Article Synopsis
- There is a lack of discharge protocols for acute pancreatitis (AP) patients, which the Hungarian Pancreatic Study Group (HPSG) aims to address with a new, validated protocol based on laboratory data and symptoms.
- An international survey revealed that 87.5% of participating medical centers do not have discharge protocols, but those that do see shorter hospital stays and lower readmission rates.
- The HPSG discharge protocol resulted in the lowest average length of hospital stay and demonstrated safety through a low readmission rate, highlighting the need for developing and validating more standardized discharge protocols for AP care.
Objective: To assess the probability of being cured of pancreatic ductal adenocarcinoma (PDAC) by pancreatic surgery.
Background: Statistical cure implies that a patient treated for a specific disease will have the same life expectancy as if he/she never had that disease.
Methods: Patients who underwent pancreatic resection for PDAC between 2010 and 2021 were retrospectively identified using a multi-institutional database.
Background: Physical prehabilitation is recommended before major abdominal surgery to ameliorate short-term outcomes.
Methods: A frequentist, random-effects network meta-analysis (NMA) was performed to clarify which type of preoperative physical activity among aerobic exercise (AE), inspiratory muscle training (IMT), and resistance training produces benefits in patients who underwent major abdominal surgery. The surface under the P-score, odds ratio (OR), or mean difference (MD) with a 95% confidence interval (CI) were reported.
Article Synopsis
- A systematic review analyzed the effects of having an aberrant right hepatic artery (a-RHA) versus a normal right hepatic artery (na-RHA) on patients undergoing pancreaticoduodenectomy (PD).
- The study found that critical outcomes, such as overall survival and complications like biliary fistula, showed no significant differences between the two groups of patients.
- The conclusion is that having an a-RHA does not negatively impact the short-term or long-term clinical outcomes following PD surgery.
Background: The benefits of immunonutrition in patients who underwent major abdominal surgery have been recently established, but the optimal combination of immunonutrients has remained unclear. The aim is to clarify this point.
Methods: A systematic search of randomized clinical trials about immunonutrition in major abdominal surgery was made.
The additive value of CA19.9 monitoring in a pancreatic cyst surveillance program.
United European Gastroenterol J
September 2023
Background: Surveillance of pancreatic cysts focuses on the detection of (mostly morphologic) features warranting surgery. European guidelines consider elevated CA19.9 as a relative indication for surgery.
View Article and Find Full Text PDFBackground: The benefits of immunonutrition (IM) in patients who underwent pancreatic surgery are unclear.
Methods: A meta-analysis of randomized clinical trials (RCTs) comparing IM with standard nutrition (SN) in pancreatic surgery was carried out. A random-effects trial sequential meta-analysis was made, reporting Risk Ratio (RR), mean difference (MD), and required information size (RIS).
Background And Aims: Body composition parameters and immunonutritional indexes provide useful information on the nutritional and inflammatory status of patients. We sought to investigate whether they predict the postoperative outcome in patients with pancreatic cancer (PC) who received neoadjuvant therapy (NAT) and then pancreaticoduodenectomy.
Methods: Data from locally advanced PC patients who underwent NAT followed by pancreaticoduodenectomy between January 2012 and December 2019 in four high-volume institutions were collected retrospectively.
Purpose: The aim is to clarify the use of perioperative chemotherapy in resectable goblet cell carcinoma (GCC).
Methods: A retrospective study was carried out based on the Surveillance, Epidemiology, and End Results study. The population was divided: into patients who received only radical surgery (group A) and those who received radical surgery plus chemotherapy (group B).
Objectives: The primary end point was the compliance rate with guidelines. The secondaries were mortality, hospital stay, and costs.
Methods: This study included 1904 patients with acute pancreatitis (AP): group A, diagnosed before 2013, and group B, after 2013.
Background: The advantages of LPD compared with OPD remain debatable. The study aimed to compare the laparoscopic (LPD) versus open (OPD) for pancreaticoduodenectomy.
Methods: A meta-analysis of randomized studies (RCTs) comparing LPD and OPD was made.
Pancreatic ductal adenocarcinoma (PDAC) is an increasing disease having a poor prognosis. The aim of the present study was to evaluate the effect of different models of care for pancreatic cancer in a tertiary referral centre in the period 2006-2020. Retrospective study of patients with PDAC observed from January 2006 to December 2020.
View Article and Find Full Text PDFBackground & Aims: Malnutrition is a well-recognized risk factor for major surgery-related complications, but the impact of preoperative nutritional therapy is still debated due to a lack of high-level evidence. The study aims to evaluate the role of preoperative malnutrition in the postoperative course of patients who underwent pancreatic resection.
Methods: This is a retrospective study involving 488 patients who underwent pancreatic resection.
Background: The safety of observing small non-functioning pancreatic neuroendocrine tumours (NF-Pan-NETs) remains under debate.
Methods: This was a multicentre retrospective study of patients with small incidental NF-Pan-NETs. Survival of patients who underwent upfront surgery versus active surveillance was compared.
Purpose: Recent studies have reported worse outcomes of converted laparoscopic distal pancreatectomy (CLDP) with respect to total laparoscopic (TLDP) and open (ODP). The aim of the study was to evaluate the impact of conversion on patient outcome and on total cost.
Methods: Patients requiring a conversion (CLDP) were compared with both TLDP and ODP patients.
Objectives: The aim of this study is to evaluate the computed tomography texture parameters in predicting grading.
Methods: This study analyzed 68 nonfunctioning pancreatic neuroendocrine neoplasms (Pan-NENs). Clinical and radiological parameters were studied.
Purpose: The best approach for minimally invasive adrenalectomy is still under debate.
Methods: A systematic search of randomized clinical trials was carried out. A frequentist random-effects network meta-analysis was made reporting the surface under the cumulative ranking (SUCRA).
Background & Aims: The preoperative use of carbohydrate loading (CHO) is recommended in patients undergoing abdominal surgery, even if the advantages remain debatable. The aim was to evaluate the CHO benefits in patients undergoing abdominal surgery.
Methods: A systematic search of randomized clinical trials was made.
Purpose: Patients submitted to curative surgery for non-functioning pancreatic neuroendocrine neoplasms (NF-PanNENs) exhibit a variable risk of disease relapse. Aims of this meta-analysis were to estimate the rate of disease recurrence and to investigate the risk factors for disease relapse in patients submitted to curative surgery for NF-PanNENs.
Methods: Medline/Pubmed and Web of Science databases were searched for relevant studies.
The study's main goal was the diagnostic adequacy of pancreatic endoscopic ultrasonographic (EUS) fine-needle biopsy (FNB) and associated predictive factors. The secondary objective was to define the diagnostic accuracy of EUS-FNB in the diagnosis of pancreatic masses and pancreatic malignancies. None of the studies reported the diagnostic adequacy and accuracy of EUS.
View Article and Find Full Text PDFBackground: A difficulty score for laparoscopic adrenalectomy (LA) is lacking in the literature. A retrospective cohort study was designed to develop a preoperative "difficulty score" for LA.
Methods: A multicenter study was conducted involving four Italian tertiary centers for adrenal disease.