Genetic Characterization of Pediatric Mixed Phenotype Acute Leukemia (MPAL).

Background/aim: Mixed phenotype acute leukemia (MPAL) is a rare hematologic malignancy in which the leukemic cells cannot be assigned to any specific lineage. The lack of well-defined, pathogenetically relevant diagnostic criteria makes the clinical handling of MPAL patients challenging. We herein report the genetic findings in bone marrow cells from two pediatric MPAL patients.

Novel and Fusion Genes in T-cell Acute Lymphoblastic Leukemia.

Background/aim: T-cell acute lymphoblastic leukemia (T-ALL) is a rare malignancy characterized by proliferation of early T-cell precursors that replace normal hematopoietic cells. T-ALL cells carry non-random chromosome aberrations, fusion genes, and gene mutations, often of prognostic significance. We herein report the genetic findings in cells from a T-ALL patient.

Chromosome Translocation t(14;21)(q11;q22) Activates Both and in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis.

Background/aim: The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene.

Materials And Methods: A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization (FISH), and immunocytochemistry.

Results: The malignant cells carried a t(14;21)(q11;q22) aberration.