Publications by authors named "Inez J Wijdh-den Hamer"

Article Synopsis
  • The study aimed to create a mathematical model to simulate mitral annular dilatation and evaluate its influence on the individualized mitral valve coaptation reserve index (CRI).
  • The research involved a retrospective analysis of 3D echocardiographic data from 25 patients undergoing cardiac surgery, focusing on measuring coaptation lengths across different regions of the mitral valve.
  • Findings indicated that the A2-to-P2 region generally had the lowest coaptation reserve index and was more susceptible to mitral regurgitation, suggesting a critical area for further investigation in mitral valve function.
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Article Synopsis
  • Mitral valve prolapse (MVP) is a widespread heart valve disease affecting over 2% of adults, yet its genetic mechanisms are not well understood and there are no current medical treatments available.
  • A comprehensive analysis of genetic data from nearly 5,000 MVP cases and over 434,000 controls uncovered 14 genetic loci linked to MVP, along with key candidate genes that may play a role in the disorder.
  • The study introduced a polygenic risk score (PRS) for MVP, enhancing the ability to predict MVP risk and potentially guiding future patient screening and therapeutic interventions.
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  • Transcatheter mitral valve replacement (TMVR) is a minimally invasive approach for treating mitral valve disease, facing challenges like various potential complications; supra-annular devices pose a lower risk since they anchor at the left atrial (LA) level.
  • An experimental study was conducted on 10 male Dorsett sheep to explore LA systolic and diastolic geometry using MRI and echocardiography after inducing ischemic mitral regurgitation (IMR) through myocardial infarction (MI), with a follow-up at 8 weeks.
  • Results showed that while there was significant IMR observed in surviving animals, key geometric parameters of the LA remained stable, providing insights for future development of TMVR devices that utilize LA
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Article Synopsis
  • High rates of recurrence in ischemic mitral regurgitation (IMR) after undersized ring annuloplasty raise concerns, prompting a study to assess the predictive value of intraoperative 3D echocardiography parameters for recurrence.
  • The study involved 35 patients and utilized advanced 3D echocardiography to analyze changes in mitral valve geometry and leaflet tethering before and after repair.
  • Results showed significant changes in valve geometry post-repair, but no intraoperative measures could predict recurrent IMR after six months, suggesting that chronic left ventricular remodeling is a key factor in ongoing IMR issues despite acute geometry adjustments.
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Aims: Fourteen Dutch heart centres collected patient-relevant outcomes to support quality improvements in a value-based healthcare initiative that began in 2012. This study aimed to evaluate the current state of outcome-based quality improvement within six of these Dutch heart centres.

Methods And Results: Interviews and questionnaires among physicians and healthcare professionals in the heart centres were combined in a mixed-methods approach.

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Objectives: Repair for ischemic mitral regurgitation with undersized annuloplasty is characterized by high recurrence rates. We sought to determine the value of pre-repair 3-dimensional echocardiography over 2-dimensional echocardiography in predicting recurrence at 6 months.

Methods: Intraoperative transesophageal 2-dimensional echocardiography and 3-dimensional echocardiography were performed in 50 patients undergoing undersized annuloplasty for ischemic mitral regurgitation.

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Background: Papillary muscle rupture (PMR) is a rare, but dramatic mechanical complication of myocardial infarction (MI), which can lead to rapid clinical deterioration and death. Immediate surgical intervention is considered the optimal and most rational treatment, despite high risks. In this study we sought to identify overall long-term survival and its predictors for patients who underwent mitral valve surgery for post-MI PMR.

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Background: Papillary muscle rupture (PMR) is a rare, but often life-threatening mechanical complication of myocardial infarction (MI). Immediate surgical intervention is considered the optimal and most rational treatment for acute PMR, but carries high risks. At this point it is not entirely clear which patients are at highest risk.

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Anomalous coronary arteries may course in close proximity to the mitral annulus, which increases the risk of iatrogenic occlusion due to annular suture placement. We report a mitral valve repair in a 55-year-old male with severe mitral regurgitation and an anomalous retro-aortic left coronary artery, originating from the right coronary sinus, coursing in close proximity to the anterior mitral annulus. To minimize iatrogenic occlusion risk an open annuloplasty ring was used with good long-term results.

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Objectives: Papillary muscle rupture (PMR) is a rare, but serious mechanical complication of myocardial infarction (MI). Although mitral valve replacement is usually the preferred treatment for this condition, mitral valve repair may offer an improved outcome. In this study, we sought to determine the outcome of mitral valve repair for post-MI PMR and to provide a systematic review of the literature on this topic.

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A 37-year-old man with end-stage idiopathic dilated cardiomyopathy underwent an orthotopic heart transplant followed by a reoperation with mitral annuloplasty for severe mitral regurgitation. Shortly thereafter, he developed severe tricuspid regurgitation and severe recurrent mitral regurgitation due to annuloplasty ring dehiscence. The dehisced annuloplasty ring was refixated, followed by tricuspid annuloplasty through a right anterolateral thoracotomy.

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Libman-Sacks endocarditis of the mitral valve was first described by Libman and Sacks in 1924. Currently, the sterile verrucous vegetative lesions seen in Libman-Sacks endocarditis are regarded as a cardiac manifestation of both systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). Although typically mild and asymptomatic, complications of Libman-Sacks endocarditis may include superimposed bacterial endocarditis, thromboembolic events, and severe valvular regurgitation and/or stenosis requiring surgery.

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Chronic ischaemic mitral regurgitation (CIMR) remains one of the most complex and unresolved aspects in the management of ischaemic heart disease. This review provides an overview of the present knowledge about the different aspects of CIMR with an emphasis on mechanisms, current surgical treatment results and new mechanism-based surgical approaches. CIMR occurs in approximately 20-25% of patients followed up after myocardial infarction (MI) and in 50% of those with post-infarct congestive heart failure (CHF).

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