Publications by authors named "Ines Wieser"
Article Synopsis
- Understanding how light interacts with DNA is crucial for improving DNA repair studies and enhancing radiotherapy methods.
- The research combines advanced techniques, like femtosecond pulsed laser microirradiation and quantitative imaging, to explore different DNA damage pathways caused by light at various wavelengths.
- Findings indicate that damage caused by two-photon photochemical reactions is significant at 515 nm, while free-electron damage prevails at higher wavelengths, and the study reveals a connection between different DNA repair mechanisms in response to this damage.
Article Synopsis
- Cellular prion protein (PrP) influences brain cell adhesion and signaling, and its infectious form is linked to neurodegenerative diseases like Creutzfeldt-Jakob disease.
- Research identifies key proteins involved in the transport of PrP, particularly highlighting the role of muskelin in regulating PrP movement and its degradation.
- Knockout of the muskelin gene leads to increased accumulation of PrP at the cell surface and accelerates the onset of prion disease in mice, suggesting its crucial role in PrP turnover and connection to neurodegenerative disease progression.
We present a three-color femtosecond Er/Yb:fiber laser enabling highly specific and standardized nonlinear optical manipulation of live cells. The system simultaneously provides bandwidth-limited 80-fs pulses with identical intensity envelope centered at wavelengths of 515, 775, and 1035 nm in the focus of a confocal microscope. We achieve this goal by combining high-order dispersion control via, for example, chirped fiber Bragg gratings with proper bandwidth management in each nonlinear conversion step.
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