Planned and unplanned pregnancies in breast cancer survivors.

Background: Nearly 20% of women presenting with breast cancer in the UK are of reproductive age. The aim of our study was to assess fertility outcome in relation to intent to conceive in patients who had completed breast cancer treatment.

Methods: Between July 2011 and December 2013, women, aged less than 43 years at the time of diagnosis, were asked during their follow-up in breast cancer clinic, to complete a questionnaire on intentions to conceive and pregnancy outcome.

Prediction of therapy response in bone-predominant metastatic breast cancer: comparison of [F] fluorodeoxyglucose and [F]-fluoride PET/CT with whole-body MRI with diffusion-weighted imaging.

Purpose: To compare [F]-fluorodeoxyglucose (FDG) and [F]-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) with whole-body magnetic resonance with diffusion-weighted imaging (WB-MRI), for endocrine therapy response prediction at 8 weeks in bone-predominant metastatic breast cancer.

Patients And Methods: Thirty-one patients scheduled for endocrine therapy had up to five bone metastases measured [FDG, NaF PET/CT: maximum standardized uptake value (SUV); WB-MRI: median apparent diffusion coefficient (ADC)] at baseline and 8 weeks. To detect the flare phenomenon, a 12-week NaF PET/CT was also performed if 8-week SUV increased.