Publications by authors named "Ines Sanchez-Lara"
Article Synopsis
- The study aimed to investigate how systemic inflammation from periodontal disease affects cognitive impairment and dementia.
- Researchers conducted a case and control study with a total of 302 participants, assessing periodontal health, cognitive impairment, and levels of inflammation through 29 biomarkers.
- The results showed some inflammatory markers linked to cognitive impairment in severe periodontitis cases, but unexpectedly, cases with cognitive impairment had lower inflammation levels compared to cognitively healthy individuals, suggesting inflammation may not significantly contribute to cognitive decline.
Background: Evidence that periodontal disease is a possible risk factor for cognitive impairment may be explained by the inflammatory hypothesis. The aim of this study is to determine whether periodontitis is related to the amyloid β (Aβ) load in blood and the role of any such relationship in the association between Aβ and cognitive impairment.
Methods: A case-control study was performed in elderly people diagnosed with cognitive impairment with or without dementia (cases group) and cognitively healthy elderly people (control group); data were collected on the medical and dental history of participants, and blood samples were drawn to determine Aβ levels using enzyme-linked immunosorbent assay.
The control of bacterial dental plaque through daily oral hygiene is essential to prevent oral diseases such as caries or periodontal disease, especially in at-risk populations, including the elderly with mild cognitive impairment and dementia. The aim of this study was to determine the association between different levels of cognitive impairment and dementia in an elderly population and their capacity to maintain adequate oral hygiene. A case-control study (elderly with versus without mild cognitive impairment or dementia) was performed in Granada, Spain.
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- This study focuses on the prevalence of dry mouth (xerostomia) in older adults with and without cognitive impairments, highlighting its negative impact on quality of life and oral health.
- Research involved comparing two groups: 200 individuals with cognitive impairments and 156 without, noting that 70.5% of those with cognitive issues reported xerostomia, compared to 36.5% in the other group.
- The study found that the use of the medication memantine significantly increased the likelihood of experiencing dry mouth, suggesting that it may be a key factor in xerostomia among older adults, regardless of other medications used.
Background: Dementia is a multi-etiologic syndrome characterized by multiple cognitive deficits but not always by the presence of cognitive impairment. Cognitive impairment is associated with multiple non-modifiable risk factors but few modifiable factors. Epidemiologic studies have shown an association between periodontitis, a potentially modifiable risk factor, and cognitive impairment.
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