Malignant melanoma in Portuguese adult population: a scoping review of the real-world evidence.

Purpose: Malignant melanoma is an aggressive cancer, and there is a notable dearth on epidemiology, clinical and treatment characterization within the Portuguese population. We performed a scoping review to identify real-world evidence studies focused in Portuguese adult patients with malignant melanoma.

Methods: A comprehensive search was conducted.

[The Glivec® case: the first example of a global debate on the drug patent system].

Objective: To describe the sequence of events involving the Glivec® case in India and to analyze the opinions generated in distinct settings.

Method: We performed a systematic search for articles concerning the imatinib (Glivec®) patent in India. We selected those sources that described the events, decisions of the authorities involved, and press and scientific opinions.

[Incremental cost evaluation study of INR self-monitoring versus laboratorial control or monitoring in health care centres, in Portugal].

Unlabelled: Oral anticoagulant therapy with vitamin K blockers has been increasing in the last few years and its effectiveness is directly related to maintaining INR values within the target range. The objective of this study is to evaluate the cost-effectiveness of INR auto-monitoring versus monitoring in a laboratory or a health care centre, in Portugal.

Methodology: The study was conducted from a social perspective and considered only the direct costs.

[Characterization of oncological disease: racional, objectives and methodology - perfil study].

Oncologic disease is one of the main causes of death in Portugal, as well as a high morbidity rate. Over the past few years, these diseases have been targeted with several strategies which aims at optimizing the use of available therapeutic and diagnostic options. Nevertheless, the amount of quantitative information available regarding the disease, patient profile, and treatment and monitoring practices is very low.

[Guidelines for prevention of febrile neutropenia].

Neutropenia and febrile neutropenia are common consequences of some cytotoxic chemotherapy regimens. This situation leads to modifications of the therapeutic regimen, conducting to either dose reduction or cycle delays. Granulocyte colony stimulating factors are commonly used to minimize chemotherapy cytotoxic effect on the granulocytic series.