Durability of tunneled catheters in children is associated with catheter tip depth: A single-center report.

The aim of this study was to examine the impact of different catheter tip positions on catheter duration and dysfunction of tunneled catheters in children. Catheters were evaluated for place of insertion, time of insertion, catheter tip depth and position, duration of use, and reason for removal. The mean duration of implanted catheters with tips placed in cavo-atrial junction/right atrium was significantly longer with significantly lower percentage of complications than tips placed in superior vena cava.

Cutaneous Metastasis as a Presenting Feature of Renal Adenocarcinoma in a Renal Transplant Recipient: A Case Report.

Cutaneous metastases of urological malignancies are a rare phenomenon. We present a case of a renal transplant recipient who presented with skin nodule 12 years posttransplant. Pathohistologic evaluation revealed metastasis from the renal adenocarcinoma.

[What doctors need to know about biosimilar medicinal products?].

Biological drug is a drug containing one or more active substances produced or secreted from a biological source. Some of them may be previously present in the human body, and examples include proteins such as insulin, growth hormone or erythropoetin. Biosimilar drug is a medical product that is a copy of the original approved drug whose patent has expired.

[Dyslipidemia and stroke in patients with chronic kidney disease].

Altered lipid and lipoprotein metabolism occurs in patients with chronic kidney disease (CKD). Dyslipidemia persists in patients on chronic hemodialysis orperitoneal dialysis and even in renal transplant recipients, and contributes to accelerated atherosclerosis but may also contribute to the progression of kidney disease as well. The etiologies of altered lipid profile in patients with CKD, dialysis, and renal transplant recipients are complex because there are profound changes in the structure and function of lipoprotein and lipid molecules, which lead to accelerated atherosclerosis, cardiovascular disease and stroke.

Rescue therapy with sirolimus in a renal transplant recipient with tacrolimus-induced hepatotoxicity.

Calcineurin inhibitors at elevated serum concentrations frequently cause mild elevation of the liver chemistries. Although rare, severe hepatotoxicity is their serious complication. A 54-year-old man with end-stage renal disease due to chronic glomerulonephritis without biopsy received a renal allograft from the deceased donor.

[A role of WNT in kidney development and function].

WNT 4 is a secreted glycoprotein that is critical for nephrogenesis during mesenchymal to epithelial transformation. Lately there are some experimental modles witch confirm a role of Wnt 4 during regeneration process in acute renal failure. On the other hand there are some evidence that Wnt 4 plays important role in renal fibrosis during experimental renal injury in rats that provide tubuloinerstitial fibrosis.

First documented case of successful kidney transplantation from a donor with acute renal failure treated with dialysis.

There is a widening gap between the needs and possibilities of kidney transplantation. In order to solve the problem of organ shortage, the selection criteria for kidney donors have been less stringent over the last years. Favorable outcome of renal transplantation from deceased donors with acute renal failure requiring dialysis may have an important role in expanding the pool of donors.

Varicella zoster virus reactivation in hemodialysis patients: manifestations, treatment, complications and outcome.

Varicella zoster virus reactivation often occurs in the setting of impaired immunity, which is generally present in patients with end-stage renal disease (ESRD). Therapy for variceIla zoster virus infection is well established. However, it is often been forgotten that acyclovir dosage should be adjusted to renal function.

[Anderson-Fabry disease and renal transplantation].

Anderson-Fabry disease is a rare disease associated with progressive accumulation of globotriaosylceramide in visceral organs and vascular endothelium. The disease primarily affects male patients. It has long been considered that females are asymptomatic carriers of Anderson-Fabry disease.

[Outcome of renal transplantation after tacrolimus switch to cyclosporine].

Calcineurin inhibitors play the key role in current immunosuppressive therapy in transplantation medicine. We present our experience with tacrolimus as immunosuppressive therapy and the reasons for replacing tacrolimus with cyclosporine in some patients. We monitored graft function, serum lipid levels, and blood glucose concentration before and after immunosuppressant switch.