Recurrent alterations are associated with esophageal adenocarcinoma brain metastases.

Unlabelled: Brain metastases in esophageal adenocarcinoma (EAC) patients are associated with poor prognosis and remain understudied. We performed multi-omics analysis with whole-genome sequencing and single-cell spatial transcriptomics on the brain metastases and matched primary tumors. Our analysis identified as a recurrent oncogene in EAC brain metastases, with 9 out of 10 cases harboring amplifications.