Publications by authors named "Ines Eichhorn"
A subset of neuroendocrine tumors (NETs) can cause an excessive secretion of hormones, neuropeptides, and biogenic amines into the bloodstream. These so-called functional NETs evoke a hormone-related disease and lead to several different syndromes, depending on the factors released. One of the most common functional syndromes, carcinoid syndrome, is characterized mainly by over-secretion of serotonin.
View Article and Find Full Text PDFOsteopontin is a prognostic circulating biomarker in patients with neuroendocrine neoplasms.
J Cancer Res Clin Oncol
September 2023
Article Synopsis
- The study investigates the role of Osteopontin (OPN) as a potential biomarker in patients with neuroendocrine neoplasms (NEN), given its elevated levels in various cancers and its involvement in tumor behavior.
- Plasma OPN concentrations were analyzed in 38 patients with NEN at different stages of their disease and compared to healthy controls, revealing significantly higher levels in NEN patients, especially in high-grade tumors.
- The findings suggest that high initial OPN levels (above 200 ng/ml) are linked to worse prognosis, indicating shorter progression-free survival, making OPN a promising prognostic biomarker for NEN patients.
Hypersecretion of glucagon contributes to abnormally increased hepatic glucose output in type 2 diabetes. Somatostatin (SST) inhibits murine glucagon secretion from isolated pancreatic islets via somatostatin receptor subtype-2 (sst2). Here, we characterize the role of sst2 in controlling glucose homeostasis in mice with diet-induced obesity.
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