Understanding Carrier Performance in Low-Dose Dry Powder Inhalation: An In VitroIn Silico Approach.

The use of physiologically based pharmacokinetic (PBPK) models to support drug product development has become increasingly popular. The in vitro characterization of the materials of the formulation provides valuable descriptors for the in silico prediction of the drug's pharmacokinetic profile. Thus, the application of an in vitroin silico framework can be decisive towards the prediction of the in vivo performance of a new medicine.