Systematic gene-disease relationship (GDR) curation unveils 61 gene-disease associations and highlights the impact on genetic testing.

Purpose: With this study, we aimed to explore the gene-disease relationship (GDR) evidence for 109 gene-disease pairs and the significance of a large Biodatabank for this classification.

Methods: The Clinical Genome Resource (ClinGen) Clinical Validity Framework for evaluation of GDR was applied. Most of the assessed genes were without a phenotype entry in the Online Mendelian Inheritance in Man (OMIM) database.

Influence of Smoking Habits on the Prevalence of Dental Caries: A Register-Based Cohort Study.

Objective: This study aimed to evaluate the influence of smoking habit on the prevalence of dental caries lesions in a follow-up study.

Materials And Methods: A total of 3,675 patients (2,186 females and 1,489 males) with an average age of 51.4 years were included.