Publications by authors named "Ines Buhler"
Recent advances in different percutaneous treatments made insertion of large-caliber sheaths in the femoral veins more common. Venous punctures are historically managed by initial manual compression with subsequent application of a compression bandage and bed rest. We describe a modified "figure-of-eight" suture technique for minimizing the risk of accidental puncture of the vein while grabbing the subcutaneous tissue.
View Article and Find Full Text PDFAims: The Edwards Sapien 3 heart valve prosthesis (S3) is commonly used for transcatheter aortic valve implantation (TAVI) and is available in three sizes. To date no data has been published on the effective orifice area (EOA) and the hemodynamic performance of the three different S3 sizes. The aim of this study was to measure the size-specific EOA and hemodynamic performance of the S3 in short-term and 1-year follow-up.
View Article and Find Full Text PDFRationale: Intracoronary delivery of autologous bone marrow-derived mononuclear cells (BM-MNC) may improve remodeling of the left ventricle (LV) after acute myocardial infarction (AMI).
Objective: To demonstrate long-term efficacy of BM-MNC treatment after AMI.
Methods And Results: In a multicenter study, we randomized 200 patients with large AMI in a 1:1:1 pattern into an open-labeled control and 2 BM-MNC treatment groups.
Treatment of structural heart disease (SHD) represents a growing need and, with increasing device availability, an increasing number of SHD can be and will be treated percutaneously. However, interventional treatment of SHD is challenging. Long procedure times and steep learning curves are recognised obstacles.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the effectiveness of the EuroScore II in predicting mortality for patients undergoing transcatheter aortic valve implantation (TAVI).
- In the analysis of 350 patients, the EuroScore II showed a significantly higher mortality prediction compared to the logistic EuroScore and the STS-PROM score, especially at the 30-day mark.
- The findings suggest that EuroScore II is a better tool for estimating both short- and long-term mortality risk among TAVI candidates, identifying patient groups as low, intermediate, and high risk based on their scores.
Background: Intracoronary administration of autologous bone marrow-derived mononuclear cells (BM-MNC) may improve remodeling of the left ventricle (LV) after acute myocardial infarction. The optimal time point of administration of BM-MNC is still uncertain and has rarely been addressed prospectively in randomized clinical trials.
Methods And Results: In a multicenter study, we randomized 200 patients with large, successfully reperfused ST-segment elevation myocardial infarction in a 1:1:1 pattern into an open-labeled control and 2 BM-MNC treatment groups.
Background: Percutaneous mitral valve repair with the MitraClip device has emerged as an alternative to surgery for treating severe mitral regurgitation. However, its effects on left ventricular loading conditions and contractility have not been investigated yet.
Methods And Results: Pressure-volume loops were recorded throughout the MitraClip procedure using conductance catheter in 33 patients (mean age, 78±10 years) with functional (45%), degenerative (48%), or mixed (6%) mitral regurgitation.
Background: Percutaneous mitral valve repair (MVR) using the MitraClip system has become a valid alternative for patients with severe mitral regurgitation (MR) and high operative risk.
Objective: To identify clinical and periprocedural factors that may have an impact on clinical outcome.
Design: Multi-centre longitudinal cohort study.
Background: Transcatheter aortic valve implantation (TAVI) has become an accepted treatment option for severe aortic stenosis (AS) in high-risk individuals. Yet, current results are difficult to compare given the lack of standardized definitions.
Methods And Results: TAVI was performed in 130 high-risk individuals.
Article Synopsis
- Recent studies suggest that giving bone marrow mononucleated cells (BM-MNCs) intracoronarily may improve heart remodeling after a heart attack, especially when administered between days 4 to 7 post-incident.
- A multicenter trial involving 192 patients with acute myocardial infarction (AMI) will assess the effectiveness of BM-MNC treatment compared to a control group receiving standard medical care, with evaluation using cardiac magnetic resonance imaging over a year.
- The primary goal is to measure changes in left ventricular ejection fraction at 4 months, while the study will also investigate the best timing for treatment and identify which patients might benefit most from cellular therapy.
Objective: The mechanisms responsible for the age-related increase in the incidence of calcific aortic valve stenosis (CAS) are unclear but may include telomere-driven cellular senescence. Because telomere length varies widely among individuals of the same age, we hypothesized that patients with shorter telomeres would be prone to develop CAS late in life.
Methods And Results: Mean telomere length was measured in leukocytes from a cohort of 193 patients > or =70 years of age with and without CAS.