Blinatumomab for First-Line Treatment of Children and Young Persons With B-ALL.

Purpose: We tested whether blinatumomab (Blina) is effective as a toxicity-sparing alternative to first-line intensive chemotherapy in children and young persons (CYP) with B-ALL who were chemotherapy-intolerant or chemotherapy-resistant.

Methods: Data were collected for consecutive CYP (age 1-24 years) with Philadelphia chromosome-positive or Philadelphia chromosome-negative B-ALL who received Blina as first-line therapy. Blina was given as replacement for postremission intensive chemotherapy to patients with chemotherapy intolerance or resistance.

Evaluation of the antioxidative response of diatoms grown on emerging steroidal contaminants.

With increasing anthropic activities, a myriad of typical contaminants from industries, hospitals, and municipal discharges have been found which fail to be categorized under regulatory standards and are hence considered contaminants of "emerging concern". Since these pollutants are not removed effectively even by the conventional treatment systems, they tend to inflict potential threats to both human and aquatic life. However, microalgae-mediated remediation strategies have recently gained worldwide importance owing to their role in carbon fixation, low operational cost, and production of high-value products.

Role of carbon-dioxide sequestering bacteria for clean air environment and prospective production of biomaterials: a sustainable approach.

The increase in demand of fossil fuel uses for developmental activity and manufacturing of goods have resulted a huge emission of global warming gases (GWGs) in the atmosphere. Among all GWGs, CO is the major contributor that inevitably causes global warming and climate change. Mitigation strategies like biological CO capture through sequestration and their storage into biological organic form are used to minimize the concentration of atmospheric CO with the goal to control climate change.

Assessing and managing people with sickle cell disease presenting with vaso-occlusive crisis in the emergency department.

Sickle cell disease is a group of inherited blood disorders characterised by atypical haemoglobin molecule structures (haemoglobin S) which can manifest as painful vaso-occlusive crises, chronic anaemia and progressive organ damage. This article aims to raise greater awareness of sickle cell disease, its acute manifestations and the potential for rapid clinical deterioration that can occur in patients with this condition. The article outlines the main aspects of the assessment and management of patients presenting to the emergency department (ED) with vaso-occlusive crisis, describes the barriers to effective care that they commonly experience and explains how their care could be improved.

Envisaging the role of pharmaceutical contaminant 17-β estradiol on growth and lipid productivity of marine diatom Chaetoceros gracilis.

In the recent past, the presence of steroid hormones in marine bodies has led to the eruption of endocrine - disrupting molecules which have detrimental effects on aquatic life. However, the resilience and robustness of diatoms to adsorb and grow under the multitude of nutrient stress allow them to utilize the plethora of such compounds. Hence, in this study, we have implemented this unique ability of diatoms to sustain on simulated steroidal wastewater made of estradiol pills and analyze their corresponding impact on growth, biomass production, and lipid synthesis.

Agro-forestry waste management- A review.

Agroforestry, an integration of farming system with woody perennials leads to the generation of potential agroforestry residues. The conventional treatment of agroforestry waste includes landfilling, thermal management, and decomposition which is accompanied with their own share of disadvantages. The ample amount of residues and products needs effective management to reap the economic and environmental benefits.

Fifteen-minute consultation: Recognition of sickle cell crises in the paediatric emergency department.

Children with sickle cell disease can develop life-threatening and painful crises that require prompt assessment and efficient management by healthcare professionals in the emergency or acute care setting. Due to migration patterns and improved survival rates in high-prevalence countries, there is an increased tendency to encounter these patients across the UK. These factors warrant regular revisions in sickle cell crisis management, along with education for medical personnel and patients to improve clinical care and patient management.

Integrated approach of whole-genome analysis, toxicological evaluation and life cycle assessment for pyrene biodegradation by a psychrophilic strain, Shewanella sp. ISTPL2.

Polycyclic aromatic hydrocarbons (PAHs) such as pyrene are universal contaminants existing in the environment which have known cancer-causing and mutagenic characteristics. A psychrophilic bacterial strain Shewanella sp. ISTPL2 was isolated from the sediment sample collected from the Pangong lake, Jammu & Kashmir, India.

Polyhydroxyalkanoate synthesis and characterization: A proteogenomic and process optimization study for biovalorization of industrial lignin.

The strain Burkholderia sp. ISTR5 (R5) was studied for polyhydroxyalkanoate (PHA) production on Kraft lignin (KL) and lignosulfonate (LS) as substrates. During the initial screening, the maximum PHA mass fraction in biomass produced on KL and LS was 23% and 18%, respectively, at 96 h.

Remediation strategies for mitigation of phthalate pollution: Challenges and future perspectives.

Phthalates are a group of emerging xenobiotic compounds commonly used as plasticizers. In recent times, there has been an increasing concern over the risk of phthalate exposure leading to adverse effects to human health and the environment. Therefore, it is necessary to not only understand the current status of phthalate pollution, their sources, exposure routes and health impacts, but also identify remediation technologies for mitigating phthalate pollution.

Genomic insights into waste valorized extracellular polymeric substances (EPS) produced by Bacillus sp. ISTL8.

The present study discusses the genomic analysis of Bacillus sp. ISTL8 along with the production of EPS (Extracellular polymeric substances) using carbofuran, a toxic carbamate pesticide. Bacillus strain was isolated from landfill soil and evaluated for high growth rates and EPS production.

Biosorption of Cr (VI) from aqueous solution by extracellular polymeric substances (EPS) produced by Parapedobacter sp. ISTM3 strain isolated from Mawsmai cave, Meghalaya, India.

In the current study, EPS producing strain Parapedobacter sp. ISTM3 was isolated from Mawsmai cave, Meghalaya, India. The strain ISTM3 showed enhanced EPS production (4.

Burkholderia: An Untapped but Promising Bacterial Genus for the Conversion of Aromatic Compounds.

Burkholderia, a bacterial genus comprising more than 120 species, is typically reported to inhabit soil and water environments. These Gram-negative bacteria harbor a variety of aromatic catabolic pathways and are thus potential organisms for bioremediation of sites contaminated with aromatic pollutants. However, there are still substantial gaps in our knowledge of these catabolic processes that must be filled before these pathways and organisms can be harnessed for biotechnological applications.

Environmental DNA and RNA as Records of Human Exposome, Including Biotic/Abiotic Exposures and Its Implications in the Assessment of the Role of Environment in Chronic Diseases.

Most of environment-related diseases often result from multiple exposures of abiotic and/or biotic stressors across various life stages. The application of environmental DNA/RNA (eDNA/eRNA) to advance ecological understanding has been very successfully used. However, the eminent extension of eDNA/eRNA-based approaches to estimate human exposure to biotic and/or abiotic environmental stressors to understand the environmental causes of chronic diseases has yet to start.

Synthesis of calcite-based bio-composite biochar for enhanced biosorption and detoxification of chromium Cr (VI) by Zhihengliuella sp. ISTPL4.

The current study presents a comprehensive analysis of the potential of actinobacterium Zhihengliuella sp. ISTPL4 and different composite materials for the removal of hexavalent chromium [Cr (VI)]. Genome analysis of strain indicated the presence of several oxidoreductases which includes chromate reductase, nitrate reductase, thioredoxin, superoxide dismutase and hydrogenase are other major candidate genes.

Biodiesel production from transesterification of Serratia sp. ISTD04 lipids using immobilised lipase on biocomposite materials of biomineralized products of carbon dioxide sequestrating bacterium.

Production of biodiesel from lipids of Serratia sp. ISTD04 by lipase of Pseudomonas sp. ISTPL3 immobilised on biocomposite materials to increase the enzyme stability and reusability was studied.

Algae as potential feedstock for the production of biofuels and value-added products: Opportunities and challenges.

The current review explores the potential application of algal biomass for the production of biofuels and bio-based products. The variety of processes and pathways through which bio-valorization of algal biomass can be performed are described in this review. Various lipid extraction techniques from algal biomass along with transesterification reactions for biodiesel production are briefly discussed.

Genomic analysis of sp. ISTR5 for biofunneling of lignin-derived compounds.

Background: Lignin is the second most abundant natural polymer on earth. Industries using lignocellulosic biomass as feedstock generate a considerable amount of lignin as a byproduct with minimal usage. For a sustainable biorefinery, the lignin must be utilized in improved ways.

Enhanced biogas production from municipal solid waste via co-digestion with sewage sludge and metabolic pathway analysis.

The present study intends to evaluate the potential of co-digestion for utilizing Organic fraction of Municipal Solid Waste (OFMSW) and sewage sludge (SS) for enhanced biogas production. Metagenomic analysis was performed to identify the dominant bacteria, archaea and fungi, changes in their communities with time and their functional roles during the course of anaerobic digestion (AD). The cumulative biogas yield of 586.

Omics approaches for microalgal applications: Prospects and challenges.

In recent impetus of phycological research, microalgae have emerged as a potential candidate for various arena of application-driven research. Omics-based tactics are used for disentangling the regulation and network integration for biosynthesis/degradation of metabolic precursors, intermediates, end products, and identifying the networks that regulate the metabolic flux. Multi-omics coupled with data analytics have facilitated understanding of biological processes and allow ample access to diverse metabolic pathways utilized for genetic manipulations making microalgal factories more efficient.

Biological fixation of carbon dioxide and biodiesel production using microalgae isolated from sewage waste water.

The present research investigates potential of microalgae isolated from sewage treatment plant to utilize sodium bicarbonate as carbon source for CO sequestration and biodiesel production. Eight algal isolates were isolated from waste water of sewage treatment plant, Amity University Haryana, India. The most potent algal isolates were identified and characterized on the basis of growth and lipid content.

Degradation and detoxification of phenanthrene by actinobacterium Zhihengliuella sp. ISTPL4.

Polycyclic aromatic hydrocarbons (PAHs) are universal environmental contaminants of great concern with regard to their potential exposure and deleterious effect on human health. The current study is the first report of phenanthrene degradation by a psychrotolerant (15 °C), halophilic (5% NaCl), and alkalophilic (pH 8) bacterial strain Zhihengliuella sp. ISTPL4, isolated from the sediment sample of the Pangong Lake, Ladakh, Jammu and Kashmir, India.

Nitrification and denitrification processes for mitigation of nitrous oxide from waste water treatment plants for biovalorization: Challenges and opportunities.

Nitrous oxide (NO) is a potent greenhouse gas. Even though its emissions is much lesser than CO but its global warming potential (GWP) is 298 times more than CO. NO emissions from wastewater treatment plants was caused due to incomplete nitrification or incomplete denitrification catalyzed by ammonia-oxidizing bacteria and heterotrophic denitrifiers.