Antiviral potential and in silico insights of polyphenols as sustainable phytopharmaceuticals: A comprehensive review.

Polyphenols, particularly flavonoids, are reported to have health-promoting, disease-preventing abilities, and several polyphenols have a wide spectrum of antiviral activities that can be explored for preventive and or therapeutic purposes. We have compiled the updated literature of diverse polyphenols active against common viral diseases, including Herpes, Hepatitis, influenza, rota, SARS-corona-viruses, etc. The antiviral activity of bioactive polyphenols depends on the hydroxyl and ester groups of polyphenol molecules, as compounds with five or more hydroxyl groups and three specific methoxy groups showed antiviral potential, like anti-rabies activity.

Traversing the potential of phytoremediation and phycoremediation as pioneering technologies in microplastic mitigation - A critical review.

With the advent of numerous reports related to health and environmental hazards associated with microplastics (MPs), scientists have been engrossed in developing sustainable technologies for MP mitigation. Conventional methods for the remediation of MPs have several limitations, but with the increasing demand for biological mitigation methods, the latest technologies are prioritized. Among biological-driven methods, phytoremediation and phycoremediation are the two peaking approaches that have gained momentum because of their eco-friendliness, cost-effectiveness, and recyclability options.

Efficacy of exopolysaccharide in dye-laden wastewater treatment: A comprehensive review.

The discharge of dye-laden wastewater into the water streams causes severe water and soil pollution, which poses a global threat to aquatic ecosystems and humans. A diverse array of microorganisms such as bacteria, fungi, and algae produce exopolysaccharides (EPS) of different compositions and exhibit great bioflocculation potency to sustainably eradicate dyes from water bodies. Nanomodified chemical composites of EPS enable their recyclability during dye-laden wastewater treatment.

Beyond the cradle - Amidst microplastics and the ongoing peril during pregnancy and neonatal stages: A holistic review.

Advancements in research concerning the occurrence of microplastics (MPs) in human blood, sputum, urine, and breast milk samples have piqued the interest of the scientific community, prompting further investigation. MPs present in the placenta, amniotic fluid, and meconium raise concerns about interference with embryonic development, leading to preeclampsia, stillbirth, preterm birth, and spontaneous abortion. The challenges posed by MPs extend beyond pregnancy, affecting the digestive, reproductive, circulatory, immune, and central nervous systems.

Zinc binding to the HCCH motif of HIV-1 virion infectivity factor induces a conformational change that mediates protein-protein interactions.

Virion infectivity factor (Vif) is an accessory protein encoded by HIV-1 and is critical for viral infection of the host CD4(+) T cell population. Vif induces ubiquitination and subsequent degradation of Apo3G, a cytosolic cytidine deaminase that otherwise targets the retroviral genome. Interaction of Vif with the cellular Cullin5-based E3 ubiquitin ligase requires a conserved BC box and upstream residues that are part of the conserved H-(Xaa)(5)-C-(Xaa)(17-18)-C-(Xaa)(3-5)-H (HCCH) motif.