Interplay of calcium pyrophosphate crystals, oxidative stress, and clinical features on knee osteoarthritis severity.

Background: Deposition of calcium pyrophosphate (CPP) crystals is observed in most joints affected by severe osteoarthritis (OA). CPP may cause local damage by inducing an inflammatory process and oxidative stress (OS).

Objectives: To evaluate inflammation and OS induced by CPP deposition and their association with the degree of knee OA.