Long-term outcomes and immune profiling in children with multisystem inflammatory syndrome (MIS-C).

Background And Aim: Existing follow-up data after MIS-C is limited.

Purpose Of The Study: to investigate the long-term consequences in children who have undergone MIS-C.

Methods: The retrospective study included 93 children.

Clinical and immunological features in children with multisystem inflammatory syndrome associated with SARS-CoV-2.

Background And Aim: MIS-C is characterized by intense immune activation and increased production of cytokines. The aim of our study was to analyse the changes of cellular and humoral immune responses in children with MIS-C, depending on the severity of the disease.

Methods: To conduct the study, the results of clinical, hematological and immunological parameters in children with severe and extremely severe MIS-C were compared.

Comparative Analysis of Clinical and Laboratory Data in Children with Multisystem Inflammatory Syndrome Associated with SARS-CoV-2 in the Republic of Kazakhstan.

Background And Objectives: Data with more severe mutations of the SARS-CoV-2 virus, compared with the original wild-type strain of COVID-19 disease, were reported worldwide. The study aims to describe the clinical and laboratory manifestations of a multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 in the Republic of Kazakhstan and to compare the severity of the disease depending on the time of the circulating variant of SARS-CoV-2 virus.

Material And Methods: A retrospective, multicentre, nationwide study of 89 children with MIS-C who received inpatient treatment from August 1, 2020, to December 1, 2021.