SloR-SRE binding to the promoter is cooperative.

is a commensal member of the plaque microbiome. It is especially prevalent when dietary sugars are available for fermentation, generating acid byproducts that lower plaque pH and foster tooth decay. can survive in the transient conditions of the mouth, in part because it can regulate the uptake of manganese and iron during periods of feast when metal ions are available, and famine when they are limiting.

Small regulatory RNAs are mediators of the SloR regulon.

Dental caries is among the most prevalent chronic diseases worldwide. , the chief causative agent of caries, uses a 25-kDa manganese-dependent SloR protein to coordinate the uptake of essential manganese with the transcription of its virulence attributes. Small non-coding RNAs (sRNAs) can either enhance or repress gene expression, and reports in the literature ascribe an emerging role for sRNAs in the environmental stress response.

Small regulatory RNAs are mediators of the SloR regulon.

Unlabelled: Dental caries is among the most prevalent chronic infectious diseases worldwide. , the chief causative agent of caries, uses a 25 kDa manganese dependent SloR protein to coordinate the uptake of essential manganese with the transcription of its virulence attributes. Small non-coding RNAs (sRNAs) can either enhance or repress gene expression and reports in the literature ascribe an emerging role for sRNAs in the environmental stress response.