Publications by authors named "Indhuja Thirumudi"
Toxoplasma gondii an obligate intracellular parasite causes toxoplasmosis in homeothermic animals. Host invasion of this parasite is mediated by the formation of Moving Junction (MJ) complex which encompasses a network of microneme and Rhoptry Neck proteins (RONs) 2/4/5/8. Among these proteins, RON4 is the only cytosolic secretory protein that is considered as a crucial member, as it directly facilitates the motility of MJ complex by interacting with host tubulin.
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- Toxoplasma gondii is a parasite that causes various health issues in humans, including encephalitis and congenital infections, by invading host cells through a specific mechanism known as the moving junction (MJ) complex.
- The study introduces two promising compounds, NSC95522 and NSC179676, which can effectively target a key region in the AMA1 protein involved in the MJ complex formation, based on detailed virtual screening and molecular dynamics analyses.
- These compounds show strong binding affinity and have been predicted to demonstrate significant inhibitory activity against the AMA1-RON2 complex, offering a potential new strategy to fight toxoplasmosis.