Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC.

A search for new heavy particles manifested as resonances in two-jet final states is presented. The data were produced in 7 TeV proton-proton collisions by the LHC and correspond to an integrated luminosity of 315  nb⁻¹ collected by the ATLAS detector. No resonances were observed.

Behavioral correlates of television viewing in young adolescents in Turkey.

We evaluated the behavioral effects of television (TV) viewing in 860 young adolescents as reported by parents (n=581) on Child Behavior Checklist (CBCL). The mean duration of TV viewing was 2.32 ± 1.

Classification of holter registers by dynamic clustering using multi-dimensional particle swarm optimization.

In this paper, we address dynamic clustering in high dimensional data or feature spaces as an optimization problem where multi-dimensional particle swarm optimization (MD PSO) is used to find out the true number of clusters, while fractional global best formation (FGBF) is applied to avoid local optima. Based on these techniques we then present a novel and personalized long-term ECG classification system, which addresses the problem of labeling the beats within a long-term ECG signal, known as Holter register, recorded from an individual patient. Due to the massive amount of ECG beats in a Holter register, visual inspection is quite difficult and cumbersome, if not impossible.

A personalized classification system for Holter registers.

In this paper we present a personalized long-term electrocardiogram (ECG) classification framework, which can be applied to any Holter register recorded from an individual patient. Due to the massive amount of ECG beats in a Holter register, visual inspection is quite difficult and cumbersome, if not impossible. Therefore the proposed system helps professionals to quickly and accurately diagnose any latent heart disease by examining only the representative beats (the so called master key-beats) each of which is automatically extracted from a time frame of homogeneous (similar) beats.

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.

Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by enforced expression of transcription factors. Using serial live imaging of human fibroblasts undergoing reprogramming, we identified distinct colony types that morphologically resemble embryonic stem (ES) cells yet differ in molecular phenotype and differentiation potential. By analyzing expression of pluripotency markers, methylation at the OCT4 and NANOG promoters and differentiation into teratomas, we determined that only one colony type represents true iPS cells, whereas the others represent reprogramming intermediates.

Fractional particle swarm optimization in multidimensional search space.

In this paper, we propose two novel techniques, which successfully address several major problems in the field of particle swarm optimization (PSO) and promise a significant breakthrough over complex multimodal optimization problems at high dimensions. The first one, which is the so-called multidimensional (MD) PSO, re-forms the native structure of swarm particles in such a way that they can make interdimensional passes with a dedicated dimensional PSO process. Therefore, in an MD search space, where the optimum dimension is unknown, swarm particles can seek both positional and dimensional optima.

Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.

Fatty acid binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis. FABP4 has been primarily regarded as an adipocyte- and macrophage-specific protein, but recent studies suggest that it may be more widely expressed. We found strong FABP4 expression in the endothelial cells (ECs) of capillaries and small veins in several mouse and human tissues, including the heart and kidney.

Evolutionary artificial neural networks by multi-dimensional particle swarm optimization.

In this paper, we propose a novel technique for the automatic design of Artificial Neural Networks (ANNs) by evolving to the optimal network configuration(s) within an architecture space. It is entirely based on a multi-dimensional Particle Swarm Optimization (MD PSO) technique, which re-forms the native structure of swarm particles in such a way that they can make inter-dimensional passes with a dedicated dimensional PSO process. Therefore, in a multidimensional search space where the optimum dimension is unknown, swarm particles can seek both positional and dimensional optima.

A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy.

Methyldopa is known to cause the production of autoantibodies against red blood cells (RBCs), leading to a positive direct antiglobulin test (DAT) and hemolytic anemia. In about 20% of patients taking methyldopa, IgG autoantibodies develop against RBCs. However, most of the patients do not have hemolysis.

A generic and robust system for automated patient-specific classification of ECG signals.

This paper presents a generic and patient-specific classification system designed for robust and accurate detection of ECG heartbeat patterns. The proposed feature extraction process utilizes morphological wavelet transform features, which are projected onto a lower dimensional feature space using principal component analysis, and temporal features from the ECG data. For the pattern recognition unit, feedforward and fully connected artificial neural networks, which are optimally designed for each patient by the proposed multidimensional particle swarm optimization technique, are employed.

Squamous morules are functionally inert elements of premalignant endometrial neoplasia.

Squamous morules are a common component of premalignant glandular lesions that are followed by glandular, rather than squamous, carcinomas. We tested the hypothesis that the appearance of glands associated with morules predicts cancer risk, and undertook molecular testing to determine the clonal and hormonal response properties of admixed squamous and glandular elements. A total of 66 patients with squamous morules in an index endometrial biopsy had follow-up clinical data (average follow-up: interval 31 months, 2.

Automated patient-specific classification of premature ventricular contractions.

In this paper, we present an automated patient-specific electrocardiogram (ECG) beat classifier designed for accurate detection of premature ventricular contractions (PVCs). In the proposed feature extraction scheme, the principal component analysis (PCA) is applied to the dyadic wavelet transform (DWT) of the ECG signal to extract morphological ECG features, which are then combined with the temporal features to form a resultant efficient feature vector. For the classification scheme, we selected the feed-forward artificial neural networks (ANNs) optimally designed by the multi-dimensional particle swarm optimization (MD-PSO) technique, which evolves the structure and weights of the network specifically for each patient.

Early forest fire detection using radio-acoustic sounding system.

Automated early fire detection systems have recently received a significant amount of attention due to their importance in protecting the global environment. Some emergent technologies such as ground-based, satellite-based remote sensing and distributed sensor networks systems have been used to detect forest fires in the early stages. In this study, a radio-acoustic sounding system with fine space and time resolution capabilities for continuous monitoring and early detection of forest fires is proposed.

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression.

The p53 tumor suppressor is a key mediator of cellular responses to various stresses. Here, we show that under conditions of basal physiologic and cell-culture stress, p53 inhibits expression of the CD44 cell-surface molecule via binding to a noncanonical p53-binding sequence in the CD44 promoter. This interaction enables an untransformed cell to respond to stress-induced, p53-dependent cytostatic and apoptotic signals that would otherwise be blocked by the actions of CD44.

Systemic endocrine instigation of indolent tumor growth requires osteopontin.

The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we find that human breast carcinomas instigate the growth of otherwise-indolent tumor cells, micrometastases, and human tumor surgical specimens located at distant anatomical sites. This systemic instigation is accompanied by incorporation of bone-marrow cells (BMCs) into the stroma of the distant, once-indolent tumors.

Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective.

Prolongation of ovarian epithelial cancer survival depends on early detection or improved responses to chemotherapy. Gains in either have been modest at best. Understanding the diverse pathogenesis of this disease is critical to early intervention or prevention.

Human embryonic stem cell derivation from poor-quality embryos.

During in vitro fertilization, embryos deemed clinically useless based on poor morphology are typically discarded. Here we demonstrate a statistical correlation between the developmental stage of such poor-quality embryos and the yield of human embryonic stem (hES) cell lines. Early-arrested or highly fragmented embryos only rarely yield cell lines, whereas those that have achieved blastocyst stage are a robust source of normal hES cells.

Reprogramming of human somatic cells to pluripotency with defined factors.

Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the organism. Embryonic stem cells are embryo-derived cell lines that retain pluripotency and represent invaluable tools for research into the mechanisms of tissue formation. Recently, murine fibroblasts have been reprogrammed directly to pluripotency by ectopic expression of four transcription factors (Oct4, Sox2, Klf4 and Myc) to yield induced pluripotent stem (iPS) cells.

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

We investigated the influence of normal cell phenotype on the neoplastic phenotype by comparing tumors derived from two different normal human mammary epithelial cell populations, one of which was isolated using a new culture medium. Transformation of these two cell populations with the same set of genetic elements yielded cells that formed tumor xenografts exhibiting major differences in histopathology, tumorigenicity, and metastatic behavior. While one cell type (HMECs) yielded squamous cell carcinomas, the other cell type (BPECs) yielded tumors closely resembling human breast adenocarcinomas.

The distal fallopian tube: a new model for pelvic serous carcinogenesis.

Purpose Of Review: Research over the past 50 years has yielded little concrete information on the source of pelvic serous cancer in women, creating a knowledge gap that has adversely influenced our ability to identify, remove or prevent the earliest stages of the most lethal form of ovarian cancer.

Recent Findings: The distal fallopian tube is emerging as an established source of many early serous carcinomas in women with BRCA mutations (BRCA+). Protocols examining the fimbrial (SEE-FIM) end have revealed a noninvasive but potentially lethal form of tubal carcinoma, designated tubal intraepithelial carcinoma.