Disturbed B and T cell homeostasis and neogenesis in patients with ataxia telangiectasia.

Objective: Ataxia telangiectasia (AT) is a rare genetic, multi-system disorder characterized by neurodegeneration, chromosome instability, B and T cell immunodeficiency and a predisposition to cancer. We examined immunologic parameters reflecting cell development and proliferation and their relevancy to the clinical phenotype in affected individuals.

Patients And Methods: AT patients from the AT National Clinic in Israel underwent immunological investigation.