Design, Synthesis, Antimicrobial Properties, and Molecular Docking of Novel Furan-Derived Chalcones and Their 3,5-Diaryl-∆-pyrazoline Derivatives.

The present work focuses on the synthesis and preliminary structure activity relationships (SARs) of furan-derived chalcones and their corresponding ∆-pyrazoline derivatives as antimicrobial agents. Eight novel chalcone derivatives and eight ∆-pyrazoline compounds were synthesized in moderate to good isolated yields. The target compounds were evaluated as antimicrobial agents against two Gram-positive ( and ), two Gram-negative ( and ), and fungi () species.

Centering equity: Addressing structural and social determinants of health to improve maternal and infant health outcomes.

Despite decades of investment and improvements in infant health in the United States, efforts to ensure the health and well-being of birthing people, especially those from racialized and minoritized communities, have been underfunded and neglected. As a result, many birthing people do not have access to the quality care they deserve and suffer disproportionately from adverse health outcomes such as severe maternal morbidity and maternal mortality. Through a Reproductive Justice lens, this paper will discuss structural causes for maternal health disparities as well as some of the structural solutions necessary to support the correction of centuries of discrimination on the basis of race, sex, gender, and other minoritized identities.

Reimagining Perinatal Mental Health: An Expansive Vision For Structural Change.

Diagnoses of depression, anxiety, or other mental illness capture just one aspect of the psychosocial elements of the perinatal period. Perinatal loss; trauma; unstable, unsafe, or inhumane work environments; structural racism and gendered oppression in health care and society; and the lack of a social safety net threaten the overall well-being of birthing people, their families, and communities. Developing relevant policies for perinatal mental health thus requires attending to the intersecting effects of racism, poverty, lack of child care, inadequate postpartum support, and other structural violence on health.

Survey of new Mexico school health professionals regarding preparedness to support sexual minority students.

Background: For schools to be safe and supportive for students, school health professionals should be aware of the particular challenges lesbian, gay, bisexual, transgender, or questioning (LGBTQ) students face, especially the risk for discrimination, violent victimization, and depression in the school setting. We assessed school health professionals' preparedness to address needs of LGBTQ students.

Methods: We conducted a secondary analysis of data collected during a New Mexico school health conference.

Electrochemical determination of some antidiabetic drugs for type 2 diabetic patients.

Quantitative determination of rosiglitazone, pioglitazone, glimepiride and glyburide as antidiabetic drugs for type 2 diabetic patients was performed conveniently and economically using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Carbon paste (CPE) and glassy carbon (GCE) electrodes were successfully used as sensors for these drugs in Briton-Robinson (B-R) as buffer solution. The preparation of CPE and the GCE as ion selective electrodes is based on the construction of 10% standard drug ion pair with reineckate or tungstophosphate imbedded as electroactive material.

Carbon paste- and PVC membrane electrodes as sensitive sensors for the determination of antidiabetic drugs for type 2 diabetic patients.

Carbon paste- and polyvinyl chloride membrane electrodes are simple, precise, rapid and selective sensors for the determination of antidiabetic drugs for type 2 diabetic patients. These electrodes were successfully used for the potentiometric determination of rosiglitazone, pioglitazone, glimepiride and glyburide in their standard forms and also as pharmaceutical preparations. The preparation of these ion-selective electrodes for the potentiometric determination of the drug is based on the construction of a 10% standard drug-ion pair with reineckate or tungstophosphate imbedded as an electro-active material in the carbon paste or in the polyvinyl chloride membrane.

Sociocultural correlates of HIV/AIDS-related stigma in rural Jamaica.

Unlabelled: BACKGROUND; AIDS-related stigma is one of the biggest obstacles in the fight to prevent HIV transmission. Since stigma deters people from seeking treatment or getting tested for HIV, determining the factors that underpin AIDS-related stigmatization may be key to finding new ways to improve care and support for people living with HIV/AIDS (PLWHA) and to reduce new infections.

Setting: The town of Lucea and surrounding communities in the parish of Hanover, Jamaica.