AML1/ETO Fusion Gene in de novo Pediatric Acute Myeloid Leukemia: Clinical Significance and Prognostic Implications.

The characterization of leukemia-associated chromosome translocations has contributed relevant insights into our understanding of leukemia pathogenesis and has provided new specific tumor markers essential in prognostic assessment and minimal residual disease studies. The aim of this work is to study the frequency of AML1/ETO fusion gene in a series of Egyptian childhood AML cases. The clinical significance and prognostic implications of this aberration, including CR rate, duration of first CR, extramedullary leukemia (EML), and survival are investigated as well.

A panel of molecular markers in hepatitis C virus-related hepatocellular carcinoma.

Background: Hepatocellular carcinoma is triggered by many factors including infection with hepatitis C virus. The molecular basis, however, of the development of HCV-related HCC remains unknown.

Objective: This work was designated to compare the circulating levels of some molecular markers between HCV-infected and HCV-free HCC patients.