Valorization of Carapa guianensis Aubl. seeds treated by compressed n-propane.

This study evaluated the oil content obtained from andiroba seeds by pressurized n-propane at different conditions of temperature (25, 35, and 45 °C) and pressure (40, 60, and 80 bar), and conventional extraction technique using n-hexane as the solvent. Kinetic extraction curves were fitted using Sovová's mathematical model. The chemical characterization of the oil was reported as well as the protein content in the extraction by-product.

Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime.

Aim: Development of functionalized nanocomposites containing AgNPs-PVP-Glucantime to evaluate their leishmanicidal activity as a novel method for improving the pharmacological properties of the drug Glucantime against extracellular promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro to treat cutaneous leishmaniasis.

Materials & Methods: The silver nanoparticles and nanocomposites prepared containing silver nanoparticles, polyvinylpyrrolidone and different amounts of Glucantime were characterized using transmission electron microscopy, x-ray diffraction, energy-dispersive x-ray spectroscopy and ζ potential analysis; in addition, the in vitro cytotoxicity was evaluated.

Results: The nanocomposites showed an inhibitory effect on the cellular viability of promastigote forms, with values of 47.