Evaluation of different vagus nerve stimulation anatomical targets in the ear by vagus evoked potential responses.

Background: Electrical auricular vagus nerve stimulation (taVNS) is an emerging therapy. Stimuli are transported to brainstem nuclei, whereby its multiple projections reach to many subcortical and cortical areas, thus allowing the neuromodulation of several systemic physiological processes. We aim to define the best auricular target for taVNS through vagus somatosensory evoked potential (VSEP) elicited stimulating different auricular areas with different electrode sizes.

Hereditary Spastic Paraplegia and Intellectual Disability: Clinicogenetic Lessons From a Family Suggesting a Dual Genetics Diagnosis.

Hereditary spastic paraplegias (HSPs) are a heterogeneous group of genetic disorders with spastic paraparesis as the main clinical feature. Complex forms may co-occur with other motor, sensory, and cognitive impairment. A growing number of loci and genes are being identified, but still more than 50% of the patients remain without molecular diagnosis.

Anti-IGLON5 disease: A new case without neuropathologic evidence of brainstem tauopathy.

Objective: To describe the neuropathologic features and the molecular data of phosphorylated tau (pTau) in a new case of anti-IgLON5 disease.

Methods: Review of clinical data, postmortem neuropathologic examination. Biochemical analyses of pTau were performed in brain samples from the present case and from a previously described patient with anti-IgLON5 with the characteristic brainstem tauopathy.

Ictal Video-Electroencephalography Findings in Bathing Seizures: Two New Cases and Review of the Literature.

Introduction: Reflex bathing seizures are described during the course of bathing in water near body temperature. These seizures differ from other epilepsies characterized by bathing-induced seizures such as hot water epilepsy, but there are few well-described patients and only some of these have been documented by ictal video-electroencephalography.

Methods: Our objective was to characterize the clinical presentation of bathing-induced seizures demonstrated by ictal video-electroencephalographic recordings with water temperature below 38°C.

Alpha and beta oscillatory activity during a sequence of two movements.

Objective: We studied movement-related electroencephalographic oscillatory changes in the alpha and beta range during a sequence of two movements in 7 healthy volunteers, in order to investigate the relationship between these changes and each component in the sequence.

Methods: The sequence consisted of a wrist active extension-passive flexion followed by a first and second finger pincer. A total of 10.