Publications by authors named "Ina van Zantwijk"
Article Synopsis
- The study explores the relationship between cellular folate concentration and the activity of the multidrug resistance protein MRP1, which affects drug resistance in cancer cells.
- When human ovarian carcinoma cells with different MRP1 levels were deprived of folate, the efflux of a model drug decreased significantly, leading to increased drug accumulation.
- Folate depletion also heightened the effectiveness of various chemotherapeutic drugs in MRP1-overexpressing cells, suggesting that lower folate levels could potentially overcome drug resistance linked to MRP1.
The proteasome inhibitor bortezomib is a novel anticancer drug that has shown promise in the treatment of refractory multiple myeloma. However, its clinical efficacy has been hampered by the emergence of drug-resistance phenomena, the molecular basis of which remains elusive. Toward this end, we here developed high levels (45- to 129-fold) of acquired resistance to bortezomib in human myelomonocytic THP1 cells by exposure to stepwise increasing (2.
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