Publications by authors named "Ina R Fredrich"
Tumor-associated macrophages (TAM) are a diverse population of myeloid cells that are often abundant and immunosuppressive in human cancers. CXCL9 TAM has recently been described to have an antitumor phenotype and is linked to immune checkpoint response. Despite the emerging understanding of the unique antitumor TAM phenotype, there is a lack of TAM-specific therapeutics to exploit this new biological understanding.
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- - Tumor-associated macrophages (TAM) are crucial in supporting cancer growth, and targeting them could enhance cancer treatment outcomes alongside other therapies.
- - Researchers proposed a new treatment strategy called highly active myeloid therapy (HAMT), focusing on pathways like JAK, NF-κB, and TLR to boost antitumor responses.
- - Their findings showed that a specific combination of drugs delivered via nanoparticles effectively eradicated tumors in mice by transforming TAM into a more effective antitumor agent, leading to lasting improvements in cancer models.
The efficient activation of professional antigen-presenting cells-such as dendritic cells (DC)-in tumors and lymph nodes is critical for the design of next-generation cancer vaccines and may be able to provide anti-tumor effects by itself through immune stimulation. The challenge is to stimulate these cells without causing excessive toxicity. It is hypothesized that a multi-pronged combinatorial approach to DC stimulation would allow dose reductions of innate immune receptor-stimulating TLR3 agonists while enhancing drug efficacy.
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