Conversion of Anergic T Cells Into Foxp3 IL-10 Regulatory T Cells by a Second Antigen Stimulus .

T cell anergy is a common mechanism of T cell tolerance. However, although anergic T cells are retained for longer time periods in their hosts, they remain functionally passive. Here, we describe the induction of anergic CD4 T cells by intravenous application of high doses of antigen and their subsequent conversion into suppressive Foxp3 IL-10 Tr1 cells but not Foxp3 Tregs.