Serum Concentrations and Elimination Rates of Direct-Acting Oral Anticoagulants (DOACs) in Older Hip Fracture Patients Hospitalized for Surgery: A Pilot Study.

Background: Use of direct-acting oral anticoagulants (DOACs) is increasing, but knowledge about pharmacokinetics and safety in frail patients is lacking.

Objective: The aim was to determine serum concentrations and elimination rates of DOACs in older hip fracture patients hospitalized for surgery.

Methods: The study included patients ≥ 65 years of age hospitalized for acute hip fracture surgery over a period of 6 months.