Publications by authors named "Ina Hohensee"
Development, Involvement and Use of an Overarching In-House Registry for Clinical Trials.
Stud Health Technol Inform
August 2024
Introduction: Conducting clinical studies is an integral part of the clinical research repertoire of university hospitals. A wealth of organizational competences must always be available in a central location and in an up-to-date form for appropriate administration. Information such as the number of ongoing studies, and the number of enrolled participants is required for tasks related to e.
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- Brain metastases from breast cancer significantly reduce patient life expectancy, particularly in cases involving alterations in EGFR, HER2 pathways, and the loss of PTEN expression.
- PTEN loss occurs in nearly half of the analyzed samples and is notably more prevalent in triple-negative breast cancer, correlating with shorter survival times after surgery.
- Overexpressing PTEN in brain-seeking cancer cells reduces tumor cell migration and invasion by affecting the AKT pathway and glial cell interactions, indicating a critical role of PTEN in the progression of brain metastases.
Current standard systemic therapies for treating breast cancer patients with brain metastases are inefficient. Targeted therapies against human epidermal growth factor receptors are of clinical interest because of their alteration in a subset of breast cancers (BCs). We analyzed copy number, mutation status, and protein expression of epidermal growth factor receptor (EGFR), human epidermal growth factor 2 (HER2), phosphatase and tensin homologue (PTEN), and PI3K catalytic subunit (PIK3CA) in 110 ductal carcinoma in situ, primary tumor, and metastatic BC samples.
View Article and Find Full Text PDFIntroduction: With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer.
Methods: Patterns of chromosomal aberrations in primary breast tumors and brain metastases were compared with array-comparative genetic hybridization (CGH).