Hybrid Laparoendoscopic Single-Site Surgery Using a 2-mm Mini-Laparoscopic Instrument versus Conventional Three-Port Laparoscopy for Gynecologic Adnexal Diseases: A Prospective Randomized Trial.

Background: Despite the advantages of laparoendoscopic single-site surgery (LESS), it has certain limitations that include longer surgical time, larger incision, and instrument collision.

Objective: To overcome these limitations, we incorporated a suprapubic 2-mm needle forceps into our hybridized LESS (hLESS) and evaluated its efficacy for benign adnexal disease in comparison with three-port laparoscopy (TPL).

Methods: This prospective study included 61 women randomly assigned in a 1:1 ratio.

Loss of ITM2A, a novel tumor suppressor of ovarian cancer through G2/M cell cycle arrest, is a poor prognostic factor of epithelial ovarian cancer.

Objective: Integral membrane protein 2A (ITM2A) is a type 2 transmembrane protein of unknown function. The aim of this study was to investigate its expression pattern, clinical significance, and biological function in epithelial ovarian cancer.

Methods: ITM2A expression in 35 normal, 20 adenoma, 11 borderline and 90 cancerous ovarian tissues was measured by immunohistochemistry.