Extracellular NAD is a regulator for FcgammaR-mediated phagocytosis in murine macrophages.

NAD is available in the extracellular environment and elicits immune modulation such as T cell apoptosis by being used as the substrate of cell surface ADP-ribosyl transferase. However, it is unclear whether extracellular NAD affects function of macrophages expressing cell surface ADP-ribosyl transferase. Here we show that extracellular NAD enhances Fcgamma receptor (FcgammaR)-mediated phagocytosis in J774A.

Homogeneous chitosan-PLGA composite fibrous scaffolds for tissue regeneration.

Novel chitosan-poly(lactide-co-glycolide) (PLGA) composite fibers and nonwoven fibrous scaffolding matrices were designed for cartilage regeneration. A homogenous one-phase mixture of chitosan and PLGA at a ratio of 50:50 (w/w %) was successfully produced using cosolvents of 1,1,1,3,3,3-hexafluoroisopropanol and methylene chloride. A wet spinning technique was employed to fabricate composite fibrous matrices.