Publications by authors named "In-Hee Kwak"
Article Synopsis
- The study investigates inflammation's role in Parkinson's disease (PD) and Parkinson plus syndrome (PPS), focusing on early-stage patients' immune responses.
- It evaluates various peripheral inflammatory markers using blood test data from 139 PD patients, 87 PPS patients, and 139 healthy controls, excluding factors that could skew inflammation results.
- Findings show significantly higher monocyte to HDL-C (MHR) and neutrophil to HDL-C (NHR) ratios in PD and PPS patients compared to healthy controls, indicating possible inflammation-related differences in these conditions.
Article Synopsis
- Lower urinary tract symptoms (LUTS) are common in Parkinson's disease (PD) patients, and this study explores the differences in urological issues between two PD subtypes: body-first and brain-first.
- The study included 55 PD patients, categorizing them based on cardiac imaging and symptoms related to rapid eye movement sleep behavior.
- Results showed that those with body-first PD had smaller bladder volumes and higher rates of overactive bladder symptoms compared to the brain-first group, with a link between cardiac imaging results and urological dysfunction.
The accumulation of alpha-synuclein (αSyn) is widely recognized as the main pathological process in Parkinson's disease (PD). Additionally, neuroinflammation is considered to be one of the contributing mechanisms in the development of PD. In light of this, it is hypothesized that the reactive microglia exacerbate the propagation of αSyn and neurodegeneration, while the inhibition of microglial activity may mitigate these effects.
View Article and Find Full Text PDFObjective: Drug-induced parkinsonism (DIP) is a frequently encountered diagnostic possibility when considering Parkinson's disease (PD). While olfactory dysfunction is a common clinical feature in PD, the comparison of olfactory function between the two conditions remains insufficient. This study aimed to compare olfactory function, including threshold, discrimination, and identification (TDI) profiles, between PD and DIP.
View Article and Find Full Text PDFUpregulation of immunoproteasome PSMB8 is associated with Parkinson's disease.
Parkinsonism Relat Disord
September 2023
Background: Immunoproteasome, a part of ubiquitin-proteasome system, is involved in immune response as well as protein degradation. However, the relationship between immunoproteasome and Parkinson's disease (PD) was not evaluated clearly. We hypothesized that the shift of immunoproteasome attributes to PD pathogenesis due to its role in inflammation and protein homeostasis.
View Article and Find Full Text PDFBackground And Purpose: REM sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with characteristic clinical subtypes and prognosis. In addition, nigrostriatal pathway, the most vulnerable anatomical area in PD, formed neuronal network interplaying with cortical and subcortical structures, and which may cause PD clinical phenotype. We evaluated the regional selectivity of presynaptic striatal dopaminergic denervation associated with RBD in PD.
View Article and Find Full Text PDF