Publications by authors named "In Kyung Heo"
J Appl Toxicol
August 2024
Article Synopsis
- * A study was conducted on pigs to evaluate the potential risks of using L-tryptophan as a feed additive, focusing on general toxicity and EMS-related symptoms.
- * Results showed no toxic effects or EMS symptoms in the pigs, indicating that L-tryptophan and its impurities do not pose safety concerns, allowing its continued use in swine diets throughout all growth stages.
J Appl Toxicol
February 2024
Article Synopsis
- * The EMS outbreak was linked to impurities in L-tryptophan from certain manufacturing processes, not the substance itself.
- * A study with broiler chickens found no toxic effects or EMS-related symptoms from L-tryptophan in meat, suggesting that L-tryptophan and its impurities are safe as feed additives.
Food Chem Toxicol
September 2023
Article Synopsis
- * EMS can affect various organ systems, leading to inflammation in muscles, skin, and lungs, and its association with L-tryptophan supplements has become controversial.
- * Research has explored the connection between impurities in L-tryptophan products and EMS, but studies have yet to produce clear conclusions on the relationship.
Amino Acids
February 2023
Article Synopsis
- * This study focuses on creating a new analytical method to detect impurities in meat products quickly using a technique called LC-MS/MS.
- * The method successfully identifies four specific impurities in just 5 minutes, with high sensitivity and no interference from other substances in the meat, achieving detection limits below 11.2 μg/kg.
Article Synopsis
- A study assessed the safety of L-tryptophan, produced through fermentation, by giving different doses (0, 500, 1000, 2000 mg/kg/day) to male and female Sprague-Dawley rats for 90 days.
- No negative health effects were found in any of the rats, even at the highest dose, and this was confirmed during a 4-week recovery period following the treatment.
- Histological tests also showed no significant changes related to eosinophilia-myalgia syndrome, leading to the conclusion that the dried L-tryptophan product is safe for use as a feed additive.
