Publications by authors named "In Keyoung Kim"
COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway.
Hyo Eun Moon Kyunghee Byun Hyung Woo Park Jin Hyun Kim Jin Hur Hyo-Soo Kim In Keyoung Kim Jin Wook Kim Dong Gyu Kim
Exp Neurobiol
March 2015
Successful recovery from brain ischemia is limited due to poor vascularization surrounding the ischemic zone. Cell therapy with strong angiogenic factors could be an effective strategy to rescue the ischemic brain. We investigated whether cartilage oligomeric matrix protein (COMP)-Ang1, a soluble, stable and potent Ang1 variant, enhances the angiogenesis of human cord blood derived endothelial progenitor cells (hCB-EPCs) for rescuing brain from ischemic injury.
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- The study examined the impact of propofol and fentanyl on microelectrode recordings (MER) during deep brain stimulation (DBS) surgery for Parkinson's disease patients, with one side operated on while awake and the other under sedation.
- There was no significant difference in the firing rates of the neuroactivity recorded from either side, although a unique bursting pattern was more common on the sedated side.
- The combined use of propofol and fentanyl proved effective without disrupting MER signals, ultimately enhancing patient comfort while achieving positive clinical outcomes six months post-surgery.
Article Synopsis
- The study investigates mitochondrial dysfunction in dopaminergic neurons of patients with idiopathic and familial Parkinson's disease (PD) by creating a specific type of cell line from adipose tissue-derived mesenchymal stromal cells (hAD-MSCs) to better understand the disease mechanism.
- Researchers established hAD-MSCs from patients with early-onset hereditary Parkin-defect PD and late-onset idiopathic PD, finding that mitochondria in these cells were damaged compared to those from non-PD patients, indicating potential mitochondrial-related issues in PD.
- The study highlights that these immortalized cell lines could serve as valuable models for evaluating mitochondrial dysfunction and in developing diagnostic and therapeutic approaches for PD.*