Synthesis of chiral gold helicoid nanoparticles using glutathione.

Chiral plasmonic nanostructures are in high demand because of their unique optical properties, which are applicable to polarization control, chiral sensing and biomedical applications. An easy and scalable synthesis method for these nanostructures may facilitate their development further. We have reported the synthesis for 432-symmetric chiral plasmonic nanoparticles by using a seed-mediated colloidal method facilitated by a chiral amino acid and peptides.

Helicoid Grating-Coupled Surface Plasmon Resonance Sensor.

Ultrasensitive, rapid, and reliable biomolecular sensing is essential for biomedical diagnostics, requiring real-time monitoring and detection of trace samples. Optical sensing, particularly plasmonic biosensing, meets these demands through noninvasive, high-sensitivity detection based on the interaction between light and molecules. Here, we present novel plasmonic metamaterial-based sensing strategy, utilizing the circular dichroism (CD) response of grating-coupled surface plasmon resonance (SPR) from chiral nanoparticle grating structure (i.

Synthesis of Chiral Ag, Pd, and Pt Helicoids inside Chiral Silica Mold.

Chiral inorganic nanomaterials hold significant promise for various applications, including enantioselective catalysis, polarization-controlling optical devices, metamaterials, and enantioselective molecular sensors. In our previous work, we presented a method for synthesizing chiral Au 432 helicoid III (Au helicoids) from peptides and amino acids, where helical gaps are intricately arranged with 432 symmetry within single cubic nanoparticles. In this study, we have achieved the fabrication of chiral silica molds through Au etching subsequent to the silica coating of Au helicoids.

Enantioselective Molecular Detection by Surface Enhanced Raman Scattering at Chiral Gold Helicoids on Grating Surfaces.

Distinct advantages of surface enhanced Raman scattering (SERS) in molecular detection can benefit the enantioselective discrimination of specific molecular configurations. However, many of the recent methods still lack versatility and require customized anchors to chemically interact with the studied analyte. In this work, we propose the utilization of helicoid-shaped chiral gold nanoparticles arranged in an ordered array on a gold grating surface for enantioselective SERS recognition.

Chiral plasmonic sensing: From the perspective of light-matter interaction.

Molecular chirality is represented as broken mirror symmetry in the structural orientation of constituent atoms and plays a pivotal role at every scale of nature. Since the discovery of the chiroptic property of chiral molecules, the characterization of molecular chirality is important in the fields of biology, physics, and chemistry. Over the centuries, the field of optical chiral sensing was based on chiral light-matter interactions between chiral molecules and polarized light.

Selective Targeting of Nanobody-Modified Gold Nanoparticles to Distinct Cell Types.

Nanobody-modified gold nanoparticles were used to explore their ability to achieve selective targeting in vitro and in vivo to distinct cell type(s), based on the specificity of the nanobody that was installed. We developed conjugation methods that exploit click chemistry for octahedral ∼50 nm gold nanoparticles and chiral ∼180 nm gold nanoparticles. We determined that each of these particles could be modified with ∼75 and ∼330 nanobodies, respectively.

Effect of Having a Usual Source of Care on Medical Expenses - Using the Korea Health Panel Data.

Background: There is a controversy about the effect of having a usual source of care on medical expenses. Although many studies have shown lower medical expenses in a group with a usual source of care, some have shown higher medical expenses in such a group. This study aimed to empirically demonstrate the effect of having a usual source of care on medical expenses.

Cardiovascular responses to endotracheal intubation in patients with acute and chronic spinal cord injuries.

Unlabelled: Endotracheal intubation usually causes transient hypertension and tachycardia. We investigated whether the cardiovascular responses to intubation change as a function of the time elapsed in patients with spinal cord injury. One-hundred-six patients with traumatic complete spinal cord injury were grouped into acute and chronic groups according to the time elapsed (less than and more than 4 wk after injury) and into those with quadriplegia and paraplegia according to the level of injury (above C7 and below T5): acute quadriplegia, n = 26; chronic quadriplegia, n = 27; acute paraplegia, n = 24; and chronic paraplegia, n = 29.

Nitrous oxide attenuates pressor but augments norepinephrine response to laryngoscopy and endotracheal intubation.

Unlabelled: Nitrous oxide (N(2)O) exerts a sympathomimetic action. We investigated whether N(2)O modifies the cardiovascular responses to tracheal intubation during general anesthesia. One-hundred healthy patients were assigned randomly to receive one of four concentrations (0%, 25%, 50%, or 75%; n = 25 each) of N(2)O in oxygen throughout the study beginning 3 min before tracheal intubation.