Exploration of thiazine Schiff bases as promising urease inhibitors: Design, synthesis, enzyme inhibition, kinetic analysis, ADME/T evaluation, and molecular docking studies.

Urease catalyzes the hydrolysis of urea, leading to an increase in stomach pH and supporting Helicobacter pylori survival, which is linked to several gastrointestinal disorders. In this study, thiazine-based Schiff bases were explored as promising urease inhibitors. Various spectroscopic techniques characterized the synthetic library of thiazine Schiff bases 2-36 and also evaluated for their inhibitory activities against urease.

Enhanced machining of Al 10%SiC 1%SiC hybrid composite using rotary tool rotary workpiece EDM with bio dielectrics and treated tools.

A sustainable approach was proposed to address environmental pollution, carbon footprint and economic efficiency challenges in Electrical Discharge Machining (EDM). This approach involved the use of Bio-dielectric such as biodiesel and Bio fuel (distilled water with 10% ethanol). The EDM process performance was further optimized by experimenting with both electrodes' rotation (i.

Evaluating the Efficacy of Plant Extracts in Managing the Bruchid Beetle, (Coleoptera: Bruchidae).

An estimated 2000 plant species have been employed for pest control worldwide. The use of these botanical derivatives is thought to be one of the most cost-effective and sustainable options for pest management in stored grain. The present study was designed to assess the efficacy of five plant extracts viz; L.

A patent review of P2X7 receptor antagonists to treat inflammatory diseases (2018-present).

Introduction: The purinergic P2X7 receptor (P2X7R) is expressed on the surface of many different types of cells, including immune cells. Targeting P2X7R with antagonists has been studied for its potential therapeutic effects in a variety of inflammatory illnesses.

Area Covered: Many chemical substances, including carboxamides, benzamides and nitrogen containing heterocyclic derivatives have demonstrated promising inhibitory potential for P2X7 receptor.

Predictive modelling and identification of key risk factors for stroke using machine learning.

Strokes are a leading global cause of mortality, underscoring the need for early detection and prevention strategies. However, addressing hidden risk factors and achieving accurate prediction become particularly challenging in the presence of imbalanced and missing data. This study encompasses three imputation techniques to deal with missing data.

Evaluation of Insecticidal Potentials of Five Plant Extracts against the Stored Grain Pest, (Coleoptera: Bruchidae).

Plant based insecticides are considered among the most economic and ecofriendly chemicals for the protection of plants and stored grains. The cowpea weevil () causes more than 90% damage to sored grains in three to six months. The current study investigates insecticidal potentials of five selected botanicals: , and They are explored at six different concentrations (0.

Recent Developments and Anticancer Therapeutics of Paclitaxel: An Update.

Plants are a source of diverse classes of secondary metabolites with anticancer properties. Paclitaxel (Taxol) is an anticancer drug isolated from various Taxus species and is used as a chemotherapeutic agent against various cancers. The biosynthesis of paclitaxel is a complex pathway, making its total chemical synthesis commercially non-viable; hence, alternative novel sources - like plant cell culture and heterologous expression systems, are being investigated to overcome this issue.

Seroprevalence of Anti-tTg-IgA among Symptomized Celiac Disease Patients and Their Correlation with Rotavirus Infection.

Celiac disease (CD) is a chronic inflammatory disorder in the intestinal tract as a response to the use of gluten in genetically predisposed individuals. It is a worldwide problem, with a high prevalence rate in North America. This is a descriptive cross-sectional study involving 1090 samples collected from different hospitals of Rawalpindi and Islamabad, Pakistan, from January 2019 to December 2019.

Biorational Control of (Coleoptera: Buchidae) in Stored Grains with Botanical Extracts.

Globally, around 2000 plant species are used against pest control. The utilization of botanicals is considered the most economic and biodegradable methods for the control of stored grains pests. Therefore, the current study was carried out to investigate the repellency potential of five botanicals against F.

Development, Molecular Docking, and ADME Evaluation of Selective ALR2 Inhibitors for the Treatment of Diabetic Complications Suppression of the Polyol Pathway.

Diabetic complications are associated with overexpression of aldose reductase, an enzyme that catalyzes the first step of the polyol pathway. Osmotic stress in the hyperglycemic state is linked with the intracellular accumulation of sorbitol along with the depletion of NADPH and eventually leads to oxidative stress formation of reactive oxygen species and advanced glycation end products (AGEs). These kinds of mechanisms cause the development of various diabetic complications including neuropathy, nephropathy, retinopathy, and atherosclerotic plaque formation.

Appraisal of novel azomethine-thioxoimidazolidinone conjugates as ecto-5'-nucleotidase inhibitors: synthesis and molecular docking studies.

Purinergic signaling is regulated by a group of extracellular enzymes called ectonucleotidases. One of its members , ecto-5'-nucleotidase (-e5'NT) is involved in the final step of the enzymatic hydrolysis cascade that is the conversion of adenosine monophosphate (AMP) to adenosine and therefore, involves the regulation of adenosine level in extracellular space. The overexpression of -e5'NT has been observed in various pathological conditions such as hypoxia, inflammation and cancers, and led to various complications.

Phytochemical Analysis and and Pharmacological Evaluation of Linn.

The main aim of this research was to explore Linn phytochemically and pharmacologically. Phytochemical screening is important for the isolation of active compounds before bulk extraction. The crude extracts and their fractions were screened for enzyme (urease, -glycosidase, and phosphodiesterase) inhibition assays, analgesic, anti-inflammatory, and sedative effects.

Development and exploration of novel substituted thiosemicarbazones as inhibitors of aldose reductase via in vitro analysis and computational study.

The role of aldose reductase (ALR2) in causing diabetic complications is well-studied, with overactivity of ALR2 in the hyperglycemic state leading to an accumulation of intracellular sorbitol, depletion of cytoplasmic NADPH and oxidative stress and causing a variety of different conditions including retinopathy, nephropathy, neuropathy and cardiovascular disorders. While previous efforts have sought to develop inhibitors of this enzyme in order to combat diabetic complications, non-selective inhibition of both ALR2 and the homologous enzyme aldehyde reductase (ALR1) has led to poor toxicity profiles, with no drugs targeting ALR2 currently approved for therapeutic use in the Western world. In the current study, we have synthesized a series of N-substituted thiosemicarbazones with added phenolic moieties, of which compound 3m displayed strong and selective ALR2 inhibitory activity in vitro (IC 1.

Comparative conventional preventive strategies for insect pest of okra.

The use of natural substances for pest control in agriculture is economically viable. It benefits both the human being and the environment due to its low persistence and toxicity. Therefore, the biopesticidal potential of three- plants-derived extracts (clove [], Hing [Hing ()], and Wood Ash []) was evaluated against different ' 'insect's pests on five okra varieties.

Nucleotide pyrophosphatase/phosphodiesterases (NPPs) including NPP1 and NPP2/ ATX as important drug targets: A patent review (2015-2020).

Introduction: Ectobucleotidases are a broad class of extracellular nucleotide and nucleoside hydrolyzing enzymes. Since they play a crucial role in mediating purinergic cell signalling, they are promising therapeutic targets for treatment of a range of disorders, including fibrosis, tumor metastasis, inflammation, multiple sclerosis, and autoimmune diseases. Hence selective inhibtors of ectonulceotidases are of great interest for therapeutic intervention.

Arsenic in a groundwater environment in Bangladesh: Occurrence and mobilization.

Groundwater with an excessive level of Arsenic (As) is a threat to human health. In Bangladesh, out of 64 districts, the groundwater of 50 and 59 districts contains As exceeding the Bangladesh (50 μg/L) and WHO (10 μg/L) standards for potable water. This review focuses on the occurrence, origin, plausible sources, and mobilization mechanisms of As in the groundwater of Bangladesh to better understand its environmental as well as public health consequences.

Integration of poultry manure and phosphate solubilizing bacteria improved availability of Ca bound P in calcareous soils.

A laboratory incubation experiment was executed to examine the role of phosphate solubilizing bacteria (with PSB and without PSB) and poultry manure (4, 8 and 12 t PM ha) in improving P mobilization/mineralization under four different lime regimes (4.78, 10, 15 and 20% CaCO M/M) for 56 days using three factorial complete randomized design (CRD) with triplicates. Phosphorus availability progressively increased over time irrespective of PSB inoculation, PM and lime levels.

High arsenic contamination and presence of other trace metals in drinking water of Kushtia district, Bangladesh.

Drinking water with excessive concentration levels of arsenic (As) is a great threat to human health. A hydrochemical approach was employed in 50 drinking water samples (collected from Kushtia district, Bangladesh) to examine the occurrence of geogenic As and the presence of trace metals (TMs), as well as the factors controlling As release in aquifers. The results reveal that the drinking water of shallow aquifers is highly contaminated by As (6.

Host Selection Behavior of the Green Peach Aphid, , in Response to Volatile Organic Compounds and Nitrogen Contents of Cabbage Cultivars.

Plants emit volatile organic compounds (VOCs) in response to herbivore attack. VOCs emitted from the Chinese cabbage cultivars in response to the damage by the green peach aphid, , were unknown. Using a solid-phase microextraction-based headspace collection method, we investigated and compared the emissions of VOCs from seven Chinese cabbage cultivars (Qibao, Qingan 80, Lvlong, Yuanbao, Qingan 70, Jinlv, and Lvqiu 66) in response to attack.

Suppressing photorespiration for the improvement in photosynthesis and crop yields: A review on the role of S-allantoin as a nitrogen source.

Environmental variations resulting in biotic and abiotic stresses demand adaptive changes in the photosynthetic machinery. To cope with these challenges, plant scientists are constantly striving to enhance photosynthetic activity. The photorespiration pathway, which fixes O and releases CO in C plants, competes with photosynthesis.