[Liver transplantation in Wilson's disease patients, 1996-2017].

Wilson's disease is a lethal-without-treatment inherited disorder of copper metabolism. Despite the increased focus on the diagnosis and treatment, liver transplantation is needed in a number of cases even nowadays. To collect and analyze the data of the Hungarian Wilson's disease patients who underwent liver transplantation.

[Surgical treatment of secondary liver malignancies].

Surgical treatment of liver metastases, under certain conditions, can be a step of a multidisciplinary treatment strategy for advanced malignant disease. Nevertheless, it is not the same if metachronous or synchronous metastases are planned to be treated. Indications for surgery are the most clearly defined and accepted in cases of colorectal and neuroendocrine liver metastases.

[Liver transplantation in the treatment of hepatic tumors].

The indications for liver transplantation have become generally accepted over the last decades. However, in the last ten years, this indication area changes, it seems to be enlarged. Increasingly, previously classified as contraindications have become indications like cholangiocarcinoma or colorectal cancer liver metastases in selected cases.

[Bacterial infection after orthotopic liver transplantation].

Introduction: The authors reviewed the prevalence of postoperative infections, the results of bacterium cultures, and the incidence of multidrug resistance in their liver transplanted patients during a period between 2003 and 2012.

Aim: The aim of this study was to analyse risk factors and colonisations of bacterial infections.

Method: The files of 408 patients (281 bacterium cultures) were reviewed.

Quantitative morphometric and immunohistochemical analysis and their correlates in cirrhosis--A study on explant livers.

Background: Reproducible structural analysis was made on cirrhotic human liver samples in order to reveal potential connections between morphological and laboratory parameters.

Material And Methods: Large histological samples were taken from segment VII of 56 cirrhotic livers removed in connection with liver transplantation. Picro Sirius red and immunohistochemically (smooth muscle actin [SMA], cytokeratin 7 [CK7], Ki-67) stained sections were digitalized and morphometric evaluation was performed.

[Infective endocarditis caused by Chlamydia pneumoniae after liver transplantation. Case report].

The incidence of infective endocarditis is underestimated in solid organ transplant recipients. The spectrum of pathogens is different from the general population. The authors report the successful treatment of a 58-year-old woman with infective endocarditis caused by atypical microorganism and presented with atypical manifestations.

Recurrence of primary sclerosing cholangitis after liver transplantation - The Hungarian experience.

Introduction: Recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (OLT) significantly affects long-term graft survival. We aimed to evaluate the incidence of rPSC and clinical data of these patients in Hungary.

Patients And Methods: We retrospectively analyzed data of 511 whole liver transplantations from 1995 to 2011.

[Hepatitis C virus recurrence after liver transplantation in Hungary. Trends over the past 10 years].

Introduction: Management of hepatitis C virus recurrence is a challenge after liver transplantation.

Aim: The aim of the authors was to analyse the outcome of liver transplantation performed in hepatitis C virus positive patients during the past ten years and to compare recent data with a previous report of the authors.

Method: The authors retrospectively evaluated the data (donors, recipients, perioperative characteristics, patient and graft survival, serum titer of hepatitis C virus RNA, histology) of 409 patients who underwent liver transplantation between 2003 and 2012.

[Kidney function and liver transplantation].

Introduction: In liver cirrhosis renal function decreases as well. Hepatorenal syndrome is the most frequent cause of the decrease, but primary kidney failure, diabetes mellitus and some diseases underlying endstage liver failure (such as hepatitis C virus infection) can also play an important role. In liver transplantation several further factors (total cross-clamping of vena cava inferior, polytransfusion, immunosuppression) impair the renal function, too.

[Progress of the liver transplantation programme in Hungary].

The history of organ transplantation in Hungary dates back to 50 years, and the first succesful liver transplantation was performed in the United States in that time as well. The number of patients with end stage liver disease increased worldwide, and over 7000 patients die in each year due to liver disease in Hungary. The most effective treatment of end-stage liver disease is liver transplantation.

[Hepatic encephalopathy and liver transplantation].

About 6500-7000 people/year die in Hungary due to liver cirrhosis which is often complicated with hepatic encephalopathy (HE). While conventional interpretation is that hepatic encephalopathy is a consequence of high blood ammonia level, recent data indicate that the degree of encephalopathy is related to systemic inflammatory response during decompensation. In this review the authors overview and analyze the latest treatment modalities of hepatic encephalopathy based on most recent findings.

Role of organ transplantation in the treatment of malignancies: hepatocellular carcinoma as the most common tumour treated with transplantation.

There are only few malignant tumours where organ transplantation is the treatment of choice. Transplantation can be considered individually in certain lung carcinomas, unresectable heart tumours, cholangiocellular carcinoma and Klatskin tumour. It is acceptable in unresectable chemosensitive hepatoblastoma, epitheloid haemangioendothelioma, liver metastasis of neuroendocrine tumours and as the most common indication, the early hepatocellular carcinoma (HCC) in cirrhotic liver.

TIPS stent migration into the heart with 6-year follow-up.

Background: The transjugular intrahepatic portosystemic shunt (TIPS) is widely used for the treatment of portal hypertension in adults, but no studies have defined the best approach to treat portal hypertension in pediatric patients. Pediatric use of TIPS is rare even in large centers of adult practice. The migration of stents has also been reported as a complication in adults.

[Hepatocellular carcinoma and liver transplantation].

In this review article author analyzes the results of liver transplantation in hepatocellular carcinoma. Due to the restrictive criteria, long term survival exceeds the results of surgical resections in many centers. With the use of biomarker des-carboxy-prothrombin, Asian transplant centers have significantly modified the previous restrictions.

[New-onset diabetes mellitus and liver transplantation, with special consideration of recurrent hepatitis C].

Unlabelled: New-onset diabetes is a common complication after liver transplantation.

Aim: We aimed to analyze the incidence and rate of known risk factors and the impact of new-onset diabetes mellitus on postoperative outcome.

Methods: We retrospectively evaluated the files of 310 patients who underwent liver transplantation between 1995 and 2009.

[The first successful adult right-lobe living donor liver transplantation in Hungary].

The authors report on their experiences related to the first adult live donor liver transplantation performed in Hungary. The transplantation was done between brother and sister on 19th of November, 2007. The right lobe of the 33-year-old healthy male's donor liver (segments 5-8) was removed and implanted into the 23-year-old female suffering from cirrhosis on the ground of autoimmune hepatitis.

[The role of marginal donors in liver transplantation. The Hungarian experience].

Unlabelled: Availability of suitable donor organs has always limited liver transplantations. Use of marginal donors (Extended Donor Criteria) for liver transplantation is an alternative to overcome the organ shortage. The aim of this study was to analyze the characteristics of organ donation in Hungary with special regard to marginal donors.

[Percutaneous transhepatic metallic stent placement for the treatment of post-transplantation portal vein stenosis].

Unlabelled: Liver transplantation is a routinely used therapeutic choice in the treatment of end stage liver disease. Portal vein stenosis is a rare vascular complication after liver transplantation. We report the interventional radiological management of three cases of portal vein stenosis.

[Investigation of renal function in liver transplant patients: MDRD or Cockroft-Gault?].

Both acute and chronic liver disease have an effect on renal function. After liver transplantation we have to pay attention to the further loss of function because of applied calcineurin inhibitor treatment. It has nephrotoxic side-effect, so the investigation of renal function is converted into an important mission in liver transplant patients.

Experimental results and clinical impact of using autologous rectus fascia sheath for vascular replacement.

Vascular complications are major causes of graft failure in liver transplantation. The use of different vascular grafts is common but the results are controversial. The aim of this study was to create an 'ideal' arterial interponate for vascular replacements in the clinical field.

[Subcapsular hematoma and rupture of the liver graft].

Subcapsular hematoma and/or rupture of the graft is uncommon but serious complication of liver transplantation. It may develop spontaneously or following parenchymal injuries or percutaneous transhepatic invasive procedures. This report describes three cases of subcapsular hematoma and/or rupture of the graft with different courses among 350 liver transplantations.

[Surgical aspects of pediatric liver transplantation. Living donor liver transplant program in Hungary].

Because of the long waiting time for pediatric liver transplantation, new techniques of liver transplantation were invented. Split and living-donor related liver transplantation are common today and the Kaplan-Meier (3 years) overall survival is over 80%. By splitting the liver, two recipients can be transplanted.

[Biliary complications following orthotopic liver transplantation. The Hungarian experience].

Introduction: The authors summarize the characteristics of biliary complications following liver transplantation in the Hungarian liver transplant program. Aims were to analyze the frequency and the types of biliary complications as well as their effect on the patient and graft survival. The authors observed the known risk factors in the Hungarian practice, and they also try to find unknown risk factors for biliary complications.