Publications by authors named "Imrankhan Khansahib"
Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca signaling in many different cell types. Here, to directly stimulate NAADP signaling, MASTER-NAADP, a Membrane permeAble, STabilized, bio-rEversibly pRotected precursor of NAADP is synthesized and release of its active NAADP mimetic, benzoic acid C-nucleoside, 2'-phospho-3'F-adenosine-diphosphate, by esterase digestion is confirmed. In the presence of NAADP receptor HN1L/JPT2 (hematological and neurological expressed 1-like protein, HN1L, also known as Jupiter microtubule-associated homolog 2, JPT2), this active NAADP mimetic releases Ca and increases the open probability of type 1 ryanodine receptor.
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- NAADP is a molecule that helps T cells start their activation by causing calcium (Ca) to be released in tiny areas called microdomains.
- Scientists found a special protein called HN1L (or JPT2) that helps NAADP work properly in this process.
- When they removed HN1L from certain T cells, it made it harder for them to produce these calcium signals quickly, showing that HN1L plays a crucial role in T cell activation.