Publications by authors named "Imran Rashid Rangraze"

The advent of new strains of resistant microbes and the concomitant growth in multidrug resistance have made antimicrobial resistance an urgent public health concern. New antimicrobials are desperately needed to boost the success rates of treating infectious diseases and save lives. There are many intriguing biomolecules with antibacterial action, which are mostly unexplored in microorganisms.

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Aim: The eventuality of tirzepatide, a binary GIP and GLP- 1 receptor agonist, as a treatment for rotundity and metabolic diseases is addressed in this comprehensive review.

Background: A definition of tirzepatide is that it is an implicit intervention for rotundity, given its effectualness per the cure-dependent effect. Beyond the beneficial effects on body weight loss, tirzepatide also brings about an improvement in lipid biographies and insulin perceptivity, in harmony with binary receptor activation.

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Article Synopsis
  • Youths with type 1 diabetes (T1D) show higher pulse wave velocity (PWV) than healthy peers, indicating a greater risk for kidney and heart issues.
  • Studies like the one by Georeli et al. link poor glycemic control (measured by time-in-range) to increased PWV in T1D patients.
  • While PWV could be useful for assessing risks in T1D, more research is needed to fully understand its implications.
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Obesity is a significant predisposing factor for heart failure with preserved ejection fraction (HFpEF). Although a substantial proportion of individuals with HFpEF also have obesity, those with obesity are under-represented in clinical trials for heart failure. In turn, current guidelines provided limited recommendations for the medical management of this patient population.

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Introduction: Incretin-based therapies have emerged as effective treatments for type 2 diabetes (T2D) and obesity. However, not all patients achieve optimal outcomes with existing treatments, highlighting the need for more effective solutions.

Areas Covered: We present a comprehensive evaluation of Tirzepatide (TZP), a novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP-1) receptor agonist, for managing obesity and T2D.

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Article Synopsis
  • Hyperinsulinemia is a condition where there’s too much insulin in the body, and it's now seen as a key part of diabetes, not just a reaction to insulin problems.
  • It affects heart health and other complications, showing that it needs more attention in diabetes care.
  • The review suggests focusing on lifestyle changes and new treatments to help manage diabetes and highlights the importance of preventing and catching diabetes early to avoid serious health issues.
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Purpose: The teacher-student dyad is the heart of an institute. A teacher's instructional role significantly influences the student engagement that indirectly measures the institutional outcome. The online transition of medical education changed the milieu of medical education where a virtual link between teacher and student is the only hope for the learner to continue the learning.

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