Breast cancer poses a significant global challenge, prompting researchers to explore novel approaches for potential treatments. For study we used thin layer chromatography (TAC) for phytochemical screening, total antioxidant capacity (TLC) assay for antioxidant capacity, and hemolytic activity test for toxicity of Neuropilins (NRPs). We performed bioinformatic analyses to predict protein structures, molecular docking, pharmacophore modeling, and virtual screening to reveal interactions with oncogenes.
View Article and Find Full Text PDFThe infection caused by Helicobacter pylori (H. pylori) disrupts the metabolism and absorption of essential trace elements. Stomach disorders are related to changes in essential trace element metabolism caused by increased toxic metal exposure and H.
View Article and Find Full Text PDFBackground: The influence of essential nutrients such as calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), selenium (Se), and zinc (Zn) on male fertility has been extensively studied. For reproductive health, adequate spermatogenesis, sperm maturation and motility, as well as optimal sperm function, these essential elements are required. Several pathologic and male infertility disorders have been linked to an imbalance of these elements.
View Article and Find Full Text PDFDIBR-3D technology has evolved over the past few years with the demands of consumers increasing in recent times for future free-view 3D videos on their home televisions. The main issue in 3D technology is the lack of 3D content available to watch using the traditional TV systems. Although, some sophisticated devices like stereoscopic cameras have been used to fill the gap between the 3D content demand and 3D content supply.
View Article and Find Full Text PDFThe purpose of this study was to evaluate the translocation of arsenic (As) from feed to different tissues of broiler chicken (leg, breast, liver and heart) and excretory product (manure). The feed, broiler chicken and manure samples were collected from five selected poultry farms. The As concentrations in all samples were determined by electrothermal atomic absorption spectrometry, after microwave assisted acid digestion in closed vessels.
View Article and Find Full Text PDFThe principal object of the current study was to estimate total arsenic and its inorganic speciation in different origins of surface water (n=480) and groundwater (n=240) of Sindh, Pakistan. This study provided a description based on the evaluation of physico-chemical parameters of collected water samples and possible distribution of As with respect to its speciation. The concentration of total inorganic As (iAs) and its species (As(3+) and As(5+)) for the surface and underground water was reported in terms of basic statistical parameters, principal component analysis, cluster analysis, metal-to-metal correlations and linear regression analyses.
View Article and Find Full Text PDFObjective: We sought to assess whether aortic valve replacement (AVR) among patients with severe aortic stenosis (AS), severe left ventricular (LV) dysfunction and a low transvalvular gradient (TVG) is associated with improved survival.
Background: The optimal management of patients with severe AS with severe LV dysfunction and a low TVG remains controversial.
Methods: Between 1990 and 1998, we evaluated 68 patients who underwent AVR at our institution (AVR group) and 89 patients who did not undergo AVR (control group), with an aortic valve area < or = 0.