Evolving patterns in the presentation of coeliac disease over the last 25 years.

Objective: To document changes in the clinical features of coeliac disease (CD) at presentation over the last 25 years.

Design: Observational study.

Patients: 802 subjects diagnosed between 1993 and 2017 at a single general hospital.

Young man presenting with recurrent food bolus impaction.

A young man with recurrent food bolus obstruction presented to the gastroenterology clinic and, after investigation, was found to have eosinophilic oesophagitis. This unusual condition is closely linked to atopy and, in parallel with other atopic conditions, is increasing in incidence. Diagnosis is confirmed on oesophageal biopsy and treatment includes topical steroids and exclusion diet.

Investigational new drugs in the treatment of inflammatory bowel disease: a review.

The unraveling of the immuno-pathobiology of inflammatory bowel disease (IBD) in the past three decades has ushered in a new era of translational medicine. The biotechnology revolution has resulted in a paradigm shift in how clinicians view and treat IBD. Anti-tumor necrosis factor (TNF)-α strategies using infliximab and adalimumab currently dominate the therapeutic arena.