Publications by authors named "Imma Izzo"
Article Synopsis
- Botulinum toxin, specifically Botulinum toxin type A (BTA), is commonly used for treating muscle hyperactivity and cosmetic purposes but can cause adverse effects like headaches and drooping eyelids.
- A study analyzing 1,464 Individual Case Safety Reports (ICSRs) found that 718 reports associated BTA with skin toxicity, predominantly affecting females aged 18-64.
- The most frequent skin-related issues included erythema, rash, and swelling, indicating a need for further research to clarify the safety profile of BTA, especially regarding hypersensitivity reactions.
Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, is authorized for the treatment of chronic lymphocytic leukemia (CLL). This study aims to explore the cardiac safety profile of ibrutinib in comparison with obinutuzumab. A retrospective pharmacovigilance study was conducted on data retrieved from the European pharmacovigilance database (Eudravigilance) from 1 January 2014 to 30 September 2022.
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- - Atrial fibrillation (AF) has been noted in COVID-19 patients and reports suggest a possible but unclear link between AF and COVID-19 vaccinations, prompting a thorough analysis of related reports in the European pharmacovigilance database from 2020 to November 2022.
- - The study reviewed 6,226 reports of AF, which constituted only 0.3% of all vaccine-related reports, predominantly affecting adults, especially those over 65, and was commonly associated with the mRNA vaccines: tozinameran (54%), elasomeran (28.3%), and ChAdOx1-S (14.32%).
- - Although hospitalization was required for 35% of the AF cases, and