Portable EEG in groups shows increased brain coupling to strong health messages.

Health messages are core building blocks of public health efforts. Neuroscientific measures offer insights into how target audiences receive health messages. To move towards real-world applications, however, challenges regarding costs, lab restraints, and slow data acquisition need to be addressed.

School well-being in primary school children with chronic illness. A prospective cohort study.

Background: Children with chronic illness perform poorer at school, and school well-being (SWB) may mediate this association. We investigated the association between chronic illness and three domains of SWB in children in first grade.

Methods: Data from a German population-based prospective cohort study were used.

A certain future strengthens the past: Knowing ahead how to act on an object prioritizes its visual working memory representation.

Findings from recent studies indicate that planning an action toward an object strengthens its visual working memory (VWM) representation, emphasizing the importance of sensorimotor links in VWM. In the present study, we investigated to what extent such sensorimotor links are modulated by how well-defined an action plan is. In three eye-tracking experiments, we asked participants to memorize a visual stimulus for a subsequent memory test, whereby they performed a specific hand movement toward memory-matching probes.

Alpha/beta oscillations reveal cognitive and affective brain states associated with role taking in a dyadic cooperative game.

Social cooperation often requires taking different roles in order to reach a shared goal. By defining individual tasks, these roles dictate processing demands of the collaborators. The main aim of the present study was to examine the hypothesis that induced alpha and lower beta oscillations provide insights into affective and cognitive brain states during social cooperation.

Dyadic cooperation with human and artificial agents: Event-related potentials trace dynamic role taking during an interactive game.

Humans are highly co-operative and thus cognitively, affectively, and motivationally tuned to pursue shared goals. Yet, cooperative tasks typically require people to constantly take and switch individual roles. Task relevance is dictated by these roles and thereby dynamically changing.

Recovery of sperm quality after COVID-19 disease in male adults under the influence of a micronutrient combination: A prospective study.

Objective: This study aims to evaluate the safety and efficacy of a standard micronutrient preparation to improve semen parameters and seminal oxidative stress in adult male subjects after Coronavirus Disease 2019 (COVID-19) disease.

Methods: For this prospective pilot study, 30 males aged 20-50 years who had recently recovered from a symptomatic SARS-CoV-2 infection were recruited from June to October 2021 through a public call for participation. Participants of the study group (n = 30) received two semen analyses according to WHO criteria at an interval of 12 weeks, during which they daily received a micronutrient preparation (L-carnitine, L-arginine, coenzyme Q10, vitamin E, zinc, folic acid, glutathione and selenium).

The effect of micronutrient supplementation on serum anti-Mullerian hormone levels: a retrospective pilot study.

Background: The anti-Müllerian-hormone (AMH) is secreted by the granulosa cells of the oocytes and can be used as a marker of the ovarian reserve; helpful to estimate female fertility or the menopause onset. Although various factors may influence AMH levels, the correlation with nutritional factors needs more research.

Objective: To evaluate the effect of a micronutrient supplementation on female AMH levels.

Total Synthesis of Shearinines D and G: A Convergent Approach to Indole Diterpenoids.

The first total syntheses of the indole diterpenoids (+)-shearinine G and D are disclosed. The successful routes rely on late-stage coupling of two complex fragments. Formation of the challenging trans-hydrindane motif was accomplished by diastereoselective, intramolecular cyclopropanation.

[Case Report: Heterotopic Retransplantation of Cryopreserved Ovarian Tissue after Adenocarcinoma of the Uterine Cervix].

Introduction: Retransplantation of cryopreserved ovarian tissue has become an established method of restoring autologous hormone production and fertility after radiotherapy and/or chemotherapy for underlying oncological disease in women of reproductive age and has so far led to more than 170 births worldwide.

Case Presentation And Course: In 2013, the 31-year-old patient developed adenocarcinoma of the uterine cervix, pT1b1V0L0. In January 2014, an extended hysterectomy with lymph node dissection and bilateral adnexectomy were performed.

Strong health messages increase audience brain coupling.

Mass media messaging is central for health communication. The success of these efforts, however, depends on whether health messages resonate with their target audiences. Here, we used electroencephalography (EEG) to capture brain responses of young adults - an important target group for alcohol prevention - while they viewed real-life video messages of varying perceived message effectiveness about risky alcohol use.

Performance Monitoring and Correct Response Significance in Conscientious Individuals.

There is sufficient evidence to believe that variations in the error-related negativity (ERN) are linked to dispositional characteristics in individuals. However, explanations of individual differences in the amplitude of the ERN cannot be derived from functional theories of the ERN. The ERN has a counterpart that occurs after correct responses (correct-response negativity, CRN).

Impressions of HIV risk online: Brain potentials while viewing online dating profiles.

There is an increasing trend to use online dating to meet potential partners. Previous studies in off-line contexts indicate that people may judge the risk of sexually transmitted infections based on a person's appearance. Online dating profiles commonly present profile pictures and verbal self-descriptions.

The impact of a standardized micronutrient supplementation on PCOS-typical parameters: a randomized controlled trial.

Purpose: To evaluate whether a micronutrient supplementation preparation that includes a high amount of omega-3 unsaturated acids, other anti-oxidants and co-enzyme Q10 would have an impact on specific serum parameters in women with polycystic ovary syndrome (PCOS).

Methods: The study was designed as a monocentral, randomized, controlled, double-blinded trial, from June 2017 to March 2018 (Clinical Trials ID: NCT03306745). Sixty women with PCOS were assigned to either the "multinutrient supplementation group" (one unlabeled soft capsule containing omega-3 fatty acids and one unlabeled tablet containing folic acid, selenium, vitamin E, catechin, glycyrrhizin, and co-enzyme Q10, for 3 months) or the "control group" (two unlabeled soft capsules containing 200 μg folic acid each, for 3 months).

Visual cues that predict intuitive risk perception in the case of HIV.

Field studies indicate that people may form impressions about potential partners' HIV risk, yet lack insight into what underlies such intuitions. The present study examined which cues may give rise to the perception of riskiness. Towards this end, portrait pictures of persons that are representative of the kinds of images found on social media were evaluated by independent raters on two sets of data: First, sixty visible cues deemed relevant to person perception, and second, perceived HIV risk and trustworthiness, health, and attractiveness.

[Experiences with an intercultural training for professionals from child-welfare services working with children and adolescents following child abuse and neglect].

Experiences with an intercultural training for professionals from child-welfare services working with children and adolescents following child abuse and neglect As part of a multicenter study evaluating measures to improve access to evidenced-based treatment for children and adolescents following child abuse and neglect, we introduced and evaluated migration-adapted services, including a one-day intercultural training. Key issues were the dissemination of information concerning migration and acculturation, trauma and mental health to immigrant families as well as the development of exercises on intercultural competence and culturally sensitive work. Near the end of the research project we gathered experiences and opinions concerning the work with immigrant families using an online survey in a subgroup of case managers working in the project (professionals in child-welfare services).

Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial.

Background/objectives: A double-blind, placebo-controlled study was performed to assess the potency of a soy germ preparation for the alleviation of menopausal hot flushes.

Subjects/methods: Caucasian women with at least seven hot flushes daily were treated with soy germ extract (100 mg isoflavone glycosides) daily or with placebo for 12 weeks, followed by 12 weeks of open treatment with soy. Outcome parameters were the number of hot flushes and the evaluation of the Greene Climacteric Scale.

Synthesis of Photoswitchable Δ-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nervous system. It has rich pharmacology and largely accounts for the recreational use of cannabis. We describe efficient asymmetric syntheses of four photoswitchable Δ-tetrahydrocannabinol derivatives (azo-THCs) from a central building block 3-Br-THC.

How real-life health messages engage our brains: Shared processing of effective anti-alcohol videos.

Health communication via mass media is an important strategy when targeting risky drinking, but many questions remain about how health messages are processed and how they unfold their effects within receivers. Here we examine how the brains of young adults-a key target group for alcohol prevention-'tune in' to real-life health prevention messages about risky alcohol use. In a first study, a large sample of authentic public service announcements (PSAs) targeting the risks of alcohol was characterized using established measures of message effectiveness.

A cross-national comparison of incident reporting systems implemented in German and Swiss hospitals.

Objective: This study aimed to empirically compare incident reporting systems (IRS) in two European countries and to explore the relationship of IRS characteristics with context factors such as hospital characteristics and characteristics of clinical risk management (CRM).

Design: We performed exploratory, secondary analyses of data on characteristics of IRS from nationwide surveys of CRM practices.

Setting: The survey was originally sent to 2136 hospitals in Germany and Switzerland.

Structural evaluations of tau protein conformation: methodologies and approaches.

Protein-misfolding diseases are based on a common principle of aggregation initiated by intra- and inter-molecular contacts. The structural and conformational changes induced by biochemical transformations such as post-translational modifications (PTMs), often lead to protein unfolding and misfolding. Thus, these order-to-disorder or disorder-to-order transitions may regulate cellular function.

Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters.

Background: There are reports showing that l-carnitine alone or in combination with other micronutrients improve sperm parameters. However, comparative studies are still lacking. This study was carried out to compare the short term effects of a combination of eight micronutrients including l-carnitine vs.

From development to aging: Holistic face perception in children, younger and older adults.

Few published reports examine the development of holistic face processing across the lifespan such that face-specific processes are adequately differentiated from general developmental effects. To address this gap in the literature, we used the complete design of the composite paradigm (Richler & Gauthier, 2014) with faces and non-face control objects (watches) to investigate holistic processing in children (8-10years), young adults (20-32years) and older adults (65-78years). Several modifications to past research designs were introduced to improve the ability to draw conclusions about the development of holistic processing in terms of face-specificity, response bias, and age-related differences in attention.

The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial.

The role of micronutrients in fertility has recently gained increased attention. We aimed to test the impact of a standardized, multinutrient supplementation on outcomes after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a pilot study. One hundred women undergoing IVF/ICSI were prospectively included and randomized to receive either a multinutrient supplementation named PROfertil® female that included folic acid, selenium, vitamin E, catechins, glycyrrhizin, diosgenin, damiana and omega-3-fatty acids (study group; n = 50), or 400 µg folic acid (control group; n = 50).

Safety and performance of cohesive polydensified matrix hyaluronic acid fillers with lidocaine in the clinical setting - an open-label, multicenter study.

Cohesive polydensified matrix (CPM) hyaluronic acid fillers are now available with or without lidocaine. The aim of this study was to investigate the safety and performance of CPM fillers with lidocaine in the clinical setting. In an open-label, prospective, postmarketing study, 108 patients from seven sites in Germany and Denmark were treated with one or more lidocaine-containing CPM fillers.

Communicating BRCA research results to patients enrolled in international clinical trials: lessons learnt from the AGO-OVAR 16 study.

Background: The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research results to individual patients.

Methods: An exploratory pharmacogenetic analysis was conducted in the international ovarian cancer phase III trial, AGO-OVAR 16, which found that patients with clinically important germ-line BRCA1/2 mutations had improved progression-free survival prognosis.