Protective effects of pentoxifylline and nimodipine on acoustic trauma in Guinea pig cochlea.

Objective: To examine the protective effects of the vasodilator and hemorheologically active drug pentoxifylline and the calcium channel blocker nimodipine on the cochlea after acoustic overexposure in guinea pigs.

Methods: Eighteen guinea pigs were used. The animals were divided into 5 groups: 1) control, 2) acoustic trauma, 3) nimodipine plus acoustic trauma, 4) pentoxifylline plus acoustic trauma, and 5) pentoxifylline plus nimodipine plus acoustic trauma.

Effect of Er:YAG and CO2 lasers with and without sodium fluoride gel on dentinal tubules: a scanning electron microscope examination.

Objective: The aim of this pilot study was to evaluate the occluding effect of erbium:yttrium-aluminum-garnet (Er:YAG) and carbon dioxide (CO2) lasers as monotherapy and in combination with topical fluoride gel on human dentinal tubules by scanning electron microscopic (SEM) examination.

Materials And Methods: Thirty-six dentine specimens with exposed dentinal tubule orifices were included in this study. The samples were divided into six groups.

Effect of oral magnesium supplementation on cisplatin ototoxicity.

Objective: The purpose of this study is to evaluate the effect of Mg supplementation on cisplatin ototoxicity in guinea pigs.

Methods: Twenty guinea pigs were divided into two groups and were fed different Mg-containing diets. Following 6 mg/kg of cisplatin injection, the animals were sacrificed and the extent of cochlear damage was assessed with the scanning electron microscope and compared with the control group.

Release behaviour and biocompatibility of drug-loaded pH sensitive particles.

The purpose of this work was to investigate the physical properties of drug-loaded poly(methacrylic acid-g-ethylene glycol) {P(MAA-g-EG)} particles, their biocompatibility with the gastrointestinal tract of rats and also the effects of these particles on the tight junctions of the rat intestinal epithelium. Model drugs such as diltiazem HCl, diclofenac Na, ciprofloxacin HCl and isoniazid were used in this study. P(MAA-g-EG) particles were prepared by free radical solution polymerization of methacrylic acid (MAA) and poly(ethylene glycol) (PEG).

Comparison of functional results of nerve graft, vein graft, and vein filled with muscle graft in end-to-side neurorrhaphy.

End-to-side neurorrhaphy is an alternative method in the situation where the proximal part of the nerve cannot be found. When the intact nerve is not close enough to perform end-to-side neurorrhaphy, it will be necessary to use a graft for transporting the regenerating axons. In this study, we tried to find out whether it is possible to use a graft in an end-to-side neurorrhaphy, and compared the nerve graft with possible alternative grafts, i.