Preparation, evaluation and pharmacokinetics of diosmin herbosome in beagle dogs.

Diosmin is one of the most widely used phlebotonic drugs, but its poor bioavailability has restricted its usage. The aim of this study was to formulate a complex Diosmin with phospholipids (75% in PC, in 1:2 molar ratios) and to evaluate for solubility, drug content, X-ray diffraction (XRD), differential scanning calorimetry (DSC) and in vitro dissolution study. Further to test the bioavailability of both the complex and Alvenor⌖ in beagle dogs and compare pharmacokinetic parameters.