Publications by authors named "Imelda R Sianipar"
Chronic liver injuries and their complications are leading causes of death, especially in developing countries (Sharma and Nagalli in Sex/Gender-Specific Medicine in the Gastrointestinal Diseases, StatPearls Publishing, 2023). The available and effective treatment plans are limited, implicating the need for innovative treatment approaches (Tsuchiya et al. in Inflamm Regener, 2019;Sharma and Nagalli in Sex/Gender-Specific Medicine in the Gastrointestinal Diseases, StatPearls Publishing, 2023;Younossi et al.
View Article and Find Full Text PDFTelerehabilitation has the potential to help expand the reach of rehabilitation intervention. An online questionnaire-based Delphi method set out to develop a telerehabilitation guideline for patients in Indonesia with Long COVID. A Delphi panel comprised of 24 experts was selected from all relevant disciplines.
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- Hematopoietic stem cell (HSC) gene therapy shows promise for treating thalassemia, but a comparison of different approaches hasn't been reviewed before.
- A systematic review analyzed six studies from various databases, focusing on how HSC gene therapy impacts globin levels, hematological parameters, and red blood cell phenotypes in animal models.
- Results indicate that HSC gene therapy significantly improves β-globin levels and red blood cell phenotypes in mice, suggesting potential efficacy for future human applications.
: Non-alcoholic Fatty Liver Disease (NAFLD) can occur as a result of micronutrient deficiencies. Hibiscus sabdarifa, a plant used in traditional medicine, contains ingredients that can help prevent this process. This study looked at the potency of Ethanol Extract (HSE) to prevent homocysteine-induced liver damage in animals that were deficient in vitamin B12.
View Article and Find Full Text PDFComparison Between Self-Deliberate Practice and Directed Learning Training Methods for Basic Life Support Knowledge and High-Quality Cardiopulmonary Resuscitation Skill Retention in Second-Year Medical Students 3 and 6 Months After Training.
Med Sci Educ
April 2023
Article Synopsis
- This study compared two CPR training methods—self-deliberate practice (SDP) and directed learning (DL)—to assess their effectiveness in improving basic life support (BLS) knowledge and CPR skills among medical students.
- Conducted with 40 medical students over a few months, both groups showed significant improvements in knowledge and skills, but there were no notable differences between the two methods in terms of outcomes.
- Both SDP and DL methods were found to be effective and retained knowledge well, proving them viable options for teaching CPR skills to students.
Hematopoietic stem cell (HSC) transplantation's success lies in its ability to induce immune reconstitution. To date, there is no review published to compare the immune reconstitution among the three sources of HSC: umbilical cord blood (UCB), bone marrow (BM), and peripheral blood (PB). The review aims to analyze the kinetic of immune reconstitution among UCB, PB, and BM in HSC transplant patients by focusing on natural killer (NK) cells, B and T lymphocytes, and neutrophils.
View Article and Find Full Text PDFIn situ simulation training for a better interprofessional team performance in transferring critically ill patients with COVID-19: a prospective randomised control trial.
Postgrad Med J
August 2022
Background: Transferring critically ill patients with COVID-19 is a challenging task; therefore, well-trained medical team is needed. This study aimed to determine the role of in situ simulation training during pandemic by using high-fidelity manikin to improve interprofessional communication, skills and teamwork in transferring critically ill patients with COVID-19.
Methods: This single-blinded randomised control trial included 40 subjects allocated into standard low-fidelity simulator (LFS) and high-fidelity simulator (HFS) groups.
Background And Aims: Recent studies underlie the importance of intestinal permeability and chronic inflammation in the pathogenesis of T2DM. Our study compared the concentrations of FABP2 and YKL40 as markers of intestinal permeability and inflammation among normoglycemia, prediabetes and T2DM.
Methods: We recruited 122 participants (45 normoglycemic, 26 prediabetes, and 51 T2DM) of whom we measured the fasting serum levels of FABP2 and YKL-40 using ELISA method.
Article Synopsis
- Obesity contributes to FGF21 resistance, impairing the ability of adipose tissue to regulate body heat and fat, primarily through increased levels of miR-34a.
- The study investigates the effects of Hibiscus sabdariffa Linn. extract (HSE) on miR-34a and FGF21 receptor expression in white adipose tissue using a rat model of diet-induced obesity.
- Results indicate that HSE can restore miR-34a and FGFR1 receptor levels to those similar to healthy controls, suggesting it has potential to combat FGF21 resistance in obesity.
Anti-inflammatory Effects of Hibiscus Sabdariffa Linn. on the IL-1β/IL-1ra Ratio in Plasma and Hippocampus of Overtrained Rats and Correlation with Spatial Memory.
Kobe J Med Sci
October 2018
Overtraining leads to an increase in IL-1β systemically due to muscle microtrauma, which affects the hippocampus, an important structure in spatial memory consolidation. The administration of Hibiscus sabdariffa Linn is expected to decrease IL-1β and increase IL-1ra, thereby potentially preventing impairments in spatial memory consolidation. This research was an experimental study using 20 male Wistar rats.
View Article and Find Full Text PDFHepatitis C virus (HCV) NS5A protein plays crucial roles in viral RNA replication, virus assembly, and viral pathogenesis. Although NS5A has no known enzymatic activity, it modulates various cellular pathways through interaction with cellular proteins. HCV NS5A (and other HCV proteins) are reportedly degraded through the ubiquitin-proteasome pathway; however, the physiological roles of ubiquitylation and deubiquitylation in HCV infection are largely unknown.
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- Hepatitis C virus (HCV) not only affects the liver but also leads to conditions such as type 2 diabetes by suppressing glucose uptake through the downregulation of the glucose transporter 2 (GLUT2).
- The study found that HCV decreases the expression of hepatocyte nuclear factor 1α (HNF-1α), which is crucial for regulating the GLUT2 gene, primarily through lysosomal degradation of the HNF-1α protein.
- The interaction between HCV's NS5A protein and HNF-1α contributes to the suppression of GLUT2 expression, indicating that HCV may cause metabolic disorders related to glucose processing.